Publications by authors named "Aleksandra Slaba"
Eur J Pharm Sci
December 2024
Article Synopsis
- The study investigates the use of different grades of hydrogenated phospholipids (HPL) as excipients in solid dispersions for the drug fenofibrate (FEN), showing that both binary and ternary blends can enhance the drug's solubility.
- X-ray diffraction analysis confirmed that ternary blends achieved complete conversion of crystalline FEN to an amorphous state, leading to better drug release compared to binary blends and marketed formulations.
- Results indicated that the formulations containing higher levels of phosphatidylcholine demonstrated improved drug permeation, suggesting that HPL blends created via hot melt extrusion could be a promising option for formulating poorly water-soluble drugs like FEN.
