[The role of CR1 complement receptor in pathology].

CR1 (Complement Receptor 1, CD35) is a membrane receptor for C3b and C4b expressed on erythrocytes, leukocytes and podocytes. It plays an important role in removal of immune complexes and pathogens coated with C3b and C4b. It also regulates the complement cascade activation by preventing formation of classical and alternative pathway convertases and by acting as a cofactor for factor 1 mediated cleavage of C3b to iC3b, C3c and C3dg.

[The structure and role of CR1 complement receptor in physiology].

CR1 (Complement Receptor type 1, C3bR, CD35) is a polymorphic glycoprotein expressed on erythrocytes, leukocytes and glomerular podocytes. It consists of extracellular, transmembrane and cytoplasmic domains. Soluble form of CR1 (sCR1), lacking the transmembrane and cytoplasmic domains, is present in serum.

The Comparison of the Podocyte Expression of Synaptopodin, CR1 and Neprilysin in Human Glomerulonephritis: Could the Expression of CR1 be Clinically Relevant?

Podocytes are considered as the most important cells that determine loss of structure and function of the glomerular filter. We compared the expression of three podocyte markers, i.e.