Publications by Aleksandra Olshanova

Publications by authors named "Aleksandra Olshanova"

Page 1 of 1

Not Every Hit-Identification Technique Works on 1-Deoxy-d-Xylulose 5-Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign.

Sandra Johannsen Robin M Gierse Aleksandra Olshanova Ellie Smerznak Christian Laggner

ChemMedChem

June 2023

In this work, we demonstrate how important it is to investigate not only on-target activity but to keep antibiotic activity against critical pathogens in mind. Since antimicrobial resistance is spreading in bacteria such as Mycobacterium tuberculosis, investigations into new targets are urgently needed. One promising new target is 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) of the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway.

View Article and Find Full Text PDF

- Aleksandra Olshanova's recent research emphasizes the significance of both on-target activity and antibiotic effectiveness against critical pathogens, particularly in the context of rising antimicrobial resistance.
- The study specifically focuses on 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) as a promising target in the fight against bacteria such as Mycobacterium tuberculosis, highlighting the need for novel therapeutic strategies.
- The research, published in "ChemMedChem," showcases a virtual screening campaign aimed at optimizing hit-identification techniques, illustrating the challenge of ensuring effective antibacterial activity against the identified target.

Publications by authors named "Aleksandra Olshanova"

Not Every Hit-Identification Technique Works on 1-Deoxy-d-Xylulose 5-Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign.

Synopsis of recent research by authors named "Aleksandra Olshanova"