Publications by authors named "Aleksandra Maciejczuk"
Article Synopsis
- Human myxovirus resistance 2 (MX2) inhibits HIV-1 and herpesviruses post-entry by interacting with viral capsids.
- Researchers identified that MX2 interacts with numerous FG-rich proteins and forms multiprotein condensates essential for its antiviral activity.
- These condensates trap the viral capsids and disrupt their entry into the nucleus, effectively preventing the viruses from delivering their genomes into host cells.
Leber hereditary optic neuropathy (LHON) is a rare disorder causing a sudden painless loss of visual acuity in one or both eyes, affecting young males in their second to third decade of life. The molecular background of the LHON is up to 90%, genetically defined by a point mutation in mitochondrial DNA. Recently, an autosomal recessive form of LHON (LHONAR1, arLHON) has been discovered, caused by biallelic variants in the gene.
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