Detection of somatic mutations in ctDNA derived from adenocarcinoma patients - EGFR tyrosine kinase inhibitor monitoring preliminary study.

Aim Of The Study: The main purpose of this study was to assess detection of mutations in the epidermal growth factor receptor (EGFR) gene in circulating tumor DNA (ctDNA) as a tool for EGFR tyrosine kinase inhibitor (TKI) monitoring therapy.

Material And Methods: The study was conducted using 20 samples from 7 adenocarcinoma patients treated with TKIs. Blood samples for ctDNA analysis were collected in 2015-2016.

Results of surgical treatment of primary lung cancer with synchronous brain metastases.

Introduction: The surgical treatment of non-small cell lung cancer (NSCLC) with synchronous brain matastases is more effective than other therapeutic options, but this management is still controversial.

The Aim Of The Study: The aim of the study was to evaluate the survival of patients after pulmonary resection NSCLC preceded by resection of brain metastases.

Material And Methods: From 2007 to 2012, 645 patients underwent pulmonary resection for NSCLC at our department.