Aс/Bi generator for direct synthesis of Bi-labeled bioconjugates.

Background: Bi is a short-lived radionuclide currently trialed for alpha therapy of various oncological diseases. A serious obstacle to the wide medical use is decay losses of Bi during a conventional synthesis of radiopharmaceuticals. In this work, we aimed to develop a two-column Aс/Bi generator providing the accumulation of Bi separately from the parent Ac via continuous circular separation and decay of intermediate Fr.

Gas-chemical approach to Ac/Bi radionuclide generator for medical application.

The article presents a novel gas-chemical approach for Ac/Bi generators, which provides effective separation of Bi from parent Ac. The main problem with the generators of high activity is the radiation stability of sorbents, which is not substantial in this gas-chemical method of separation, where only radiationally stable inorganic materials are used. The approach includes heating at high temperature (about 900-1000 °C) Ac sample deposited on a backing material (Nb, quartz glass, stainless steel) in hydrogen-containing inert gas flow.

Insights into Actinium Complexes with Tetraacetates─AcBATA versus AcDOTA: Thermodynamic, Structural, and Labeling Properties.

In the current research, we conducted a comparative study of the Ac complex with HDOTA and HBATA. The stability constants of the [AcBATA] and [AcDOTA] complexes were studied directly by extraction methods. We discovered that the thermodynamic properties of the [AcBATA] complex are superior to those of [AcDOTA].

Rapid Elution of Th from a Two-Column U/Th Generator with Diluted and Buffer Solutions.

A radionuclide generator of the short-lived alpha emitter Th was proposed. An original scheme consisting of two in-series chromatographic columns was developed for rapidly producing a neutral citric-buffered eluate of high purity Th. The first column filled with TEVA resin retained the parent U, while Th was eluted with 7 M HCl solution to be immediately adsorbed on the second column containing DGA resin or UTEVA resin.

DTPA(DOTA)-Nimotuzumab Radiolabeling with Generator-produced Thorium for Radioimmunotherapy of EGFR-overexpressing Carcinomas.

Introduction: The feasibility of preparing the "in-house" generators and the Th- DTPA(DOTA)-Nimotuzumab radioimmunoconjugate was evaluated. Th is perspective for TAT, however, due to short half-life it is preferable to apply this radionuclide for readily available epithelial malignancies. Nimotuzumab being specific for EGFR expressing cells as a targeting moiety is considered to be suitable for thorium delivery.

Np(v) complexation with propionate in 0.5-4 M NaCl solutions at 20-85 °C.

Low molecular weight organics (LMWO; e.g. acetate, propionate, lactate) can significantly impact the speciation and mobility of radionuclides in aqueous media.