Negative Symptoms of Schizophrenia: New Prospects of Cariprazine Treatment.

Background: Cariprazine is a new piperazine derivative atypical antipsychotic, like aripiprazole and brexpiprazole. It has been approved for treating schizophrenia in many countries and has recently been included on the List of Essential Medicines in Russia. Unlike most other atypical antipsychotics, it shows high occupancy of dopamine D2 and D3 receptors at clinically relevant doses.