Publications by authors named "Aleksandr Friman"
Article Synopsis
- PIWI-interacting RNAs (piRNAs) are vital for maintaining genome integrity by silencing mobile genetic elements and are derived from long single-stranded precursors in various species.
- The study explores how piRNA clusters form and adapt to genomic threats, presenting a roadmap of piRNA clusters in seven species, highlighting shared traits and differences.
- Findings reveal transcriptional readthrough as a mechanism for piRNA production in mammals, especially in response to retroviral threats, and uncover dynamic piRNA clusters in human germ cells, enhancing understanding of piRNA biology across species.
East African cichlid fishes have diversified in an explosive fashion, but the (epi)genetic basis of the phenotypic diversity of these fishes remains largely unknown. Although transposable elements (TEs) have been associated with phenotypic variation in cichlids, little is known about their transcriptional activity and epigenetic silencing. Here, we describe dynamic patterns of TE expression in African cichlid gonads and during early development.
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