The effect of hydrophilic base on pharmaceutical availability of prednisolone complexed with beta-cyclodextrin.

Studies on the effect of hydrophilic gel composition on pharmaceutical availability of prednisolone complexed with beta-cyklodextrin at P:beta-CD ratios 1:1 and 1:2 revealed that the half-release times were shortened and differentiated depending on the substances added hydrogel to propylene glycol, dimethylacetamide and polysorbate 20 in comparison to preparations containing non-complexed active substance.

The use of kinetic N-order model in description of active substance release from various drug forms. Part 2. Analysis of paracetamol and sodium diclofenac release from methylcellulose.

The first part of the monograph presented the premises and equations which are the basis for the proposed mathematical n-order model. This non-linear physical model obeying the laws of chemical kinetics was used to describe the processes of active substance release from drug form. The possibilities of its application in the mathematical description and detailed analysis of the kinetics of paracetamol and sodium diclofenac release from various viscosity gels based on methylcellulose were investigated.

The use of kinetic N-order model in description of active substance release from various drug forms. Part 1. Premises and mathematical analysis of the N-order model.

The paper presents the premises and equations which are the basis of the mathematical n-order model, which contrarily to standard models based on the laws of chemical kinetics, i.e. 0-order and 1-order kinetics, enables categorization of the investigated process taking into account two parameters: the rate at which it occurs, and actual order, which it is distinguished by.

[Acute, hemorrhagic, overgrowing vaginal inflammation caused by Streptococcus agalacitae--case study].

The aim of this study was to discuss a case of an acute, hemorrhagic, overgrowing vaginal inflammation caused by Streptococcus agalacitae. Intravaginal globules based on methylcellulose and gelatin, containing a lactic acid and chitosan complex in mole relation 1:1 to 4:1 and, in succesion, an addition of hydrophilisating substances like: PEG-200, propylene-1,2 glycol or glycerol, were applied in the treatment process. The technology was invented in Fac.

Preliminary evaluation of interactions between selected alcoholamines and model skin sebum components.

The aim was to evaluate the interaction between selected alcoholamines and components of artificial skin sebum. The rate and depth of penetration into the lipophilic bead imitating pilosebaceous unit lumen was applied for alcoholamine penetration activity assay. The activity differentiation of 0.

[Biodegradable polymers for colon-specific drug delivery].

This review focuses on the colonic drug delivery, especially using biodegradable polymers i.e. guar gum, chondroitin sulfate, pectin, starch and amylose, dextran, chitosan, inulin.

[Concentration influence of some polymers on dermatological hydrogels pH].

For last two decades there is a lot interest in skin pH research, and pH influence on the skin barrier function. A wide range of hydrophilic polymers are applied worldwide for topical and transdermal preparation, influencing acid mantle of the skin. One of the determinants for feasibility of the polymer for dermatological application, and for proper drug release kinetics is the pH.

[Some interactions of natural and synthetic anionic polymers with biologically active substances].

Anionic polymers are nowadays extensively used in drug form technology, especially in drug delivery and drug targeting. Development of proper drug and macromolecular excipient composition allows controlled drug delivery in the term of the drug concentration in blood or other tissues, and in the term of the action-time. Between anionic polymers most frequently carbopols, eudragits, alginates and pectins are used.

Carbopols as factors buffering triethanolamine interacting with artificial skin sebum.

Triethanolamine is an ethanolamine applied as counter-ion for fatty acid soaps. Interaction between triethanolamine and free fatty acids is suggested to be useful for cleansing sebaceous follicles in acne prevention. Considering relatively high pH of aqueous triethanolamine solutions we investigated influence of different concentrations of anionic polymers--Carbopol 934P, Carbopol 974P and Carbopol 980 on pH, rheological behavior and, most of them, intensity of triethanolamine interaction with artificial skin sebum components.

Effect of some anionic polymers on pH of triethanolamine aqueous solutions.

One of the suggested approaches in the management and prophylaxis of acne involves binding of free fatty acids in the form of soap with alcoholamines. Due to a possible irritating effect of alcoholamines associated with a relatively high pH of their aqueous solutions, complexation of alcoholamines with acid polymers is advocated. Triethanolamine is one of the best recognized alcoholamines.

Effect of natural anionic polymers on the release rate and local concentration of metronidazole at pH near the natural gastric environment.

The aim of the study was to evaluate initially the applicability of certain natural polymers, as metronidazole binding agents in the treatment of ulcerative lesions in the gastric mucous membrane. The investigation involved systems containing metronidazole in combination with sodium alginate, citrus pectin and citrus-apple pectin. The rate of metronidazole release from the investigated preparations was evaluated after acidification to pH in gastric environment.

Effect of some ethoxylated sorbitan alkanoate on hydrocortisone release from methylcellulose gels.

The process of hydrocortisone release from the nonionic polymer--methylcellulose hydrogels with the addition of 1% and 3% ethoxylated sorbitan alkanoate: polysorbate 20 or polysorbate 80, in the presence of 1,2-propylene glycol or PEG 200 has two stages. In the first stage the release rates are higher in comparison with the second stage. Concerning the hydrogel as a two-compartment system with micellas of polysorbates, the release rates of the first stage are in the range 4.

Preliminary assessment of alginic acid as a factor buffering triethanolamine interacting with artificial skin sebum.

Triethanolamine is an ethanolamine used as counter-ion for fatty acid soaps. Interaction between triethanolamine and free fatty acids is suggested to be useful for cleansing sebaceous follicles in acne prevention. This study describes the preliminary assessment of alginic acid as a factor buffering triethanolamine interacting with stearic acid--a compound of artificial skin sebum.