Distinct hippocampal-prefrontal neural assemblies coordinate memory encoding, maintenance, and recall.

Short-term memory enables incorporation of recent experience into subsequent decision-making. This processing recruits both the prefrontal cortex and hippocampus, where neurons encode task cues, rules, and outcomes. However, precisely which information is carried when, and by which neurons, remains unclear.

Altered dendritic spine function and integration in a mouse model of fragile X syndrome.

Cellular and circuit hyperexcitability are core features of fragile X syndrome and related autism spectrum disorder models. However, the cellular and synaptic bases of this hyperexcitability have proved elusive. We report in a mouse model of fragile X syndrome, glutamate uncaging onto individual dendritic spines yields stronger single-spine excitation than wild-type, with more silent spines.

Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex.

Sensory hypersensitivity is a common and debilitating feature of neurodevelopmental disorders such as Fragile X Syndrome (FXS). How developmental changes in neuronal function culminate in network dysfunction that underlies sensory hypersensitivities is unknown. By systematically studying cellular and synaptic properties of layer 4 neurons combined with cellular and network simulations, we explored how the array of phenotypes in Fmr1-knockout (KO) mice produce circuit pathology during development.

Cellular mechanisms underlying behavioral state-dependent bidirectional modulation of motor cortex output.

Neuronal activity in primary motor cortex (M1) correlates with behavioral state, but the cellular mechanisms underpinning behavioral state-dependent modulation of M1 output remain largely unresolved. Here, we performed in vivo patch-clamp recordings from layer 5B (L5B) pyramidal neurons in awake mice during quiet wakefulness and self-paced, voluntary movement. We show that L5B output neurons display bidirectional (i.

The stress of chest pain: a case of tako-tsubo cardiomyopathy.

Tako-tsubo cardiomyopathy is an important syndrome whose presentation mimics that of an acute coronary syndrome/myocardial infarction. It is a transient phenomenon characterised by chest pain, electrocardiographic changes, elevation of cardiac enzymes, apical/mid left ventricular ballooning and regional wall motion changes in the absence of significant angiographic coronary artery disease.The present report concerns a case of tako-tsubo cardiomyopathy in a 62-year-old woman admitted following stressful events.