Serologically assessed heat shock protein 47 is related to fibrosis stage in early compensated alcohol-related liver disease.

Background And Aims: Heat shock protein (HSP)47 is a collagen-specific chaperone, essential for the correct formation of fibrillar procollagens. Collagen accumulation in the extracellular matrix (ECM) is a hallmark of fibrogenesis. The expression of HSP47 is proportional to the rate of collagen formation.

[Hepatorenal syndrome: diagnosis, treatment and prevention].

Cirrhosis, ascites and renal impairment are associated with high morbidity and mortality. The hepatorenal syndrome (HRS) is a type of renal failure that affects patients with cirrhosis and ascites. This paper provides an update on evidence-based interventions in HRS.

[Treatment of bleeding from oesophageal varices in patients with cirrhosis].

This review summarizes the evidence of therapy for primary and secondary prevention of bleeding from oesophageal varices and treatment of acute bleeding. Continuing advances in the knowledge of portal hypertension have led to a reduction in primary and secondary bleeding episodes from oesophageal varices and a reduction in mortality from acute bleeding.