Acute acetaminophen overdose is associated with dose-dependent hypokalaemia: a prospective study of 331 patients.

Hypokalaemia is a recognized complication of acute acetaminophen overdose. It is unclear whether this might be a pharmacological effect of acetaminophen, or due to association with confounding factors. The present study sought to better characterize the relationship between acetaminophen concentrations and risk of hypokalaemia.