Publications by authors named "Alekhya Vadlakonda"
Article Synopsis
- Chromosome inversions play a crucial role in genome evolution by suppressing meiotic crossovers when heterozygous with standard arrangements, especially in Drosophila species.
- This study investigated the interchromosomal effect in Drosophila simulans, a species lacking natural inversions, and found no evidence of this effect despite using new techniques to create inversions.
- Analysis revealed differences in the timing of synaptonemal complex assembly and double-stranded break formation between D. simulans and D. melanogaster, indicating variations in early meiotic development.
Expansion of a single repetitive DNA sequence, termed a tandem repeat (TR), is known to cause more than 50 diseases. However, repeat expansions are often not explored beyond neurological and neurodegenerative disorders. In some cancers, mutations accumulate in short tracts of TRs, a phenomenon termed microsatellite instability; however, larger repeat expansions have not been systematically analysed in cancer.
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