Publications by authors named "Alejandro Villao"
Objective: To assess obstetrical outcomes in a sample of nulliparous gestations with preeclampsia, as compared to gestations without preeclampsia, attended in the Enrique C. Sotomayor Hospital of Guayaquil, Ecuador.
Method: This was a comparative study of maternal and perinatal outcome data of gestations with late onset preeclampsia (n=150; gestational age=36.
Article Synopsis
- The study aimed to analyze the prevalence of specific MTHFR gene mutations (C677T and A1298C SNPs) in women without children who developed preeclampsia (PE).
- One hundred fifty preeclamptic women and control subjects were genotyped, revealing that the CC genotype of the A1298C polymorphism was significantly more common in those with PE, especially correlating with larger neck circumference.
- Women with the CC genotype also exhibited elevated homocysteine plasma levels compared to controls, suggesting possible links between this genetic mutation, PE, and associated health risks like obesity and cardiovascular issues.