Synopsis of recent research by authors named "Alejandro Vila"
Alejandro Vila's recent research largely focuses on the characterization and inhibition of metallo-β-lactamases (MBLs), enzymes that contribute to antibiotic resistance by hydrolyzing β-lactam antibiotics.
Key findings include the development of novel inhibitors, such as taniborbactam, and a detailed understanding of the structural mechanisms that enable MBLs to resist both existing and newly developed antibiotics.
His studies also highlight the evolutionary adaptations of certain MBLs, providing insights into their kinetic stability and interactions with various β-lactam compounds, which could inform future therapeutic strategies against antibiotic-resistant infections.
