Publications by authors named "Alejandro Vara"
Article Synopsis
- Autologous haematopoietic stem cell transplantation (AHSCT) is a treatment for Crohn's disease that can be tough because of side effects from chemotherapy.
- In this study, 14 patients had a new approach that didn’t use cyclophosphamide (Cy), and they were given a different medication to help their bodies prepare for the transplant.
- The results showed that the treatment was safe, most patients did well after the transplant, but some had to go back on Crohn's disease medicine later on.
Background And Objectives: Combination therapy with an immunomodulator (IMM) and an anti-TNF is commonly recommended in Crohn's disease (CD) and ulcerative colitis (UC) patients. However, little is known about relapse rates after therapeutic de-escalation. This study aimed to evaluate the risk of relapse in a cohort of UC and CD patients with long-standing clinical remission after discontinuation of IMM or anti-TNF and to identify predictive factors for relapse.
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- The study looked at how to find out which patients with Crohn's disease would heal well when treated with special medicines called TNF-α inhibitors.
- They found that a big improvement in a specific test score after 14 weeks was a good sign that the patients would heal well after a year.
- Overall, basic health data didn’t help predict healing, but seeing a major drop in the disease score early on was really important to know who would get better in the long run.