Publications by authors named "Alejandro Serrano Rubio"

Background: Castleman disease (CD) is a rare lymphoproliferative disorder, with intracranial involvement being exceedingly rare. Unicentric Castleman disease (UCD) is typically benign and localized, but its presentation can mimic other intracranial pathologies, complicating diagnosis.

Case Description: We reported a 52-year-old woman who presented with progressive headaches and language disturbances.

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"True" posterior communicating artery (PComA) aneurysms are one of the rarest of all intracranial aneurysms. Diagnosis of this kind of aneurysm and treatment continue to be challenging for neurosurgeons because of the surrounding structures and their importance. Concomitant vascular anomalies, like dissections or hypoplasia, are frequently found with these aneurysms.

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Article Synopsis
  • Brain arteriovenous malformations (AVMs) are often asymptomatic but can lead to serious complications like severe headaches or bleeding; this case describes a woman who experienced a ruptured AVM causing intracerebral hemorrhage.
  • During her surgery, doctors found and removed a non-functioning pituitary adenoma alongside the AVM, revealing various vascular and inflammatory changes in both tissues.
  • Unfortunately, the patient tested positive for COVID-19 and died three days later, marking this as a rare instance of dual pathologies linked to the virus, including AVM rupture and brain infarcts.
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Background: Microsurgical treatment of paraclinoid aneurysms is a complex task that generally requires anterior clinoid process (ACP) removal to obtain adequate surgical exposure. This procedure poses a considerable technical difficulty due to the association of the ACP to critical neurovascular structures. Furthermore, anatomical variations in the parasellar region, such as the caroticoclinoid foramen (CCF) or an interclinoid bridge (ICB), may impose additional challenges and increase surgical complications.

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Background: The fluorescein videoangiography (FL-VAG) has become a valuable adjunct tool in vascular neurosurgery. This work describes using the FL-VAG during bypass surgery and proposes a classification method for evaluating surgical results.

Methods: We analyzed 26 patients with 50 cerebral bypasses from September 2018 to September 2022.

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Background: Vascular neurosurgical procedures require temporary or permanent surgical clips to treat cerebral aneurysms, arteriovenous malformations, or bypass surgery. In this scenario, surgical clips should have specific characteristics such as high-quality material, proper design, closing force, and biocompatibility. Due to these characteristics, the price of these clips does not allow their availability at the experimental surgery laboratory worldwide.

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Background: Hemifacial spasm (HFS) is characterized by involuntary, progressive, and intermittent spasms in the upper and lower facial muscles. Due to the high success rate, microvascular decompression (MVD) is the treatment of choice, and intraoperative neuromonitoring (INM) is considered useful for achieving safe surgery. Still, most centers do not have this technology.

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Background: Paraclinoid aneurysms represent a challenge for neurosurgeons due to the anatomical complexity of this region. Then, innovative techniques such as the extradural sphenoid ridge approach are suitable for a safe microsurgical clipping.

Method: A description of the surgical technique was made by the senior author, a vascular neurosurgeon experienced with the use of this approach in the management of paraclinoid aneurysms exemplified through a clinical case.

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Background: The middle cerebral artery (MCA) is a common site of cerebral aneurysms and 82.6% occur at the bifurcation. When surgery is selected as a therapeutic option, it intends to clip the neck completely because if some remnant occurs, there exists the possibility of regrowth and bleeding in the short- or long-term.

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Background: Lhermitte-Duclos disease (LDD) or dysplastic gangliocytoma of the posterior fossa is a slow-growing and extremely rare mass lesion that involves the Purkinje neurons and the granular layer of the cerebellum. It is characterized by specific neuroradiological features and secondary hydrocephalus. However, documentation of surgical experience is scarce.

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Background: , a Gram-negative organism, rarely causes an epidural spinal abscess.

Case Description: A 50-year-old male presented with mild paraparesis attributed to an magnetic resonance (MR)-documented spinal epidural abscess (SEA) at the T10-level. Following surgical debridement, cultures grew , a rare Gram-negative organism.

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Background: Anomalies of the middle cerebral artery (MCA) are rare; among the different types of anomalies, the aplastic or twig-like (Ap/T) MCA is extremely rare and has been reported under various names, including aplastic, unfused, or rete type anomaly. The occurrence of a brain aneurysm associated with this anatomic variant is an even rare event, and probably their development and rupture are related to hemodynamic stress of the tinny wall of vessels forming the network.

Case Description: We present a 43-year-old male patient with an explosive and persistent right orbitofrontal headache.

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Objective: Sylvian fissure (SF) arteriovenous malformations (AVMs) are among the most challenging vascular lesions amenable to neurosurgical treatment and account for 10% of all locations. As radiosurgery and endovascular techniques are increasingly involved in multimodal management protocols, the role of microsurgery needs to be reassessed as a stand-alone technique. The aim of this study was to show that total excision can be achieved with reasonable levels of morbidity and mortality in a real-world setting from a specialized high-volume center.

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Purpose: To describe the anatomical measurements of the trigeminal nerve in patients with trigeminal neuralgia (TN) during Linac (linear accelerator)-based stereotactic radiosurgery (SRS) simulation, targeting the root entry zone (REZ), with a 30% isodose line tangential to the pons, using 4-mm and 6-mm collimators.

Methods: In this retrospective study, 53 TN patients, who underwent Fiesta sequence scanning prior to any treatment modality, were assessed. Bilateral measurements were obtained from the cisternal segment of the trigeminal nerve, the trigeminal-pontine angle, and the lateral width of the pontine cistern on the Fiesta MRI sequence.

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Objective: To characterize dynamic changes of arteriovenous malformation using a microscope-integrated technique at the moment of performing intraoperative fluorescein videoangiography (FL-VAG) at each of the resection phases.

Methods: We prospectively recruited 12 patients with arteriovenous malformations and used FL-VAG as an ancillary technique for resection of the lesion. We analyzed transit time (TT) of FL in arterial feeders (arterial transit time [TTa]) and draining veins (venous transit time [TTv]) during the different stages of resection.

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