Publications by authors named "Alejandro Sanchez Grande Flecha"

Article Synopsis
  • Researchers studied 1,729 patients with coronary artery aneurysms (CAAs) to understand their clinical characteristics and predict outcomes, using data from an international registry across 9 countries.
  • The majority of patients were male (78.6%) averaging 66 years old, with significant cardiovascular issues such as coronary artery disease (85.8%) and a median of 1 aneurysm per patient, primarily affecting the left anterior descending artery.
  • During a median follow-up of about 45 months, 21.9% of patients died, and 37.1% experienced major adverse cardiovascular events; factors like age, diabetes, and kidney disease were linked to worse outcomes.
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Article Synopsis
  • Primary angioplasty is the standard treatment for ST-segment elevation myocardial infarction (STEMI), but it can cause additional cell damage, which levosimendan may help prevent.
  • In a study, patients received either levosimendan or a placebo after angioplasty, and their heart damage was assessed over 6 months.
  • Results showed that those treated with levosimendan had a significant reduction in infarct size compared to the placebo group, confirming its safety and effectiveness in this context.
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Background: Cardiogenic shock (CS) is a significant complication of Takotsubo syndrome (TTS), contributing to heightened mortality and morbidity. Despite this, the Society for Cardiovascular Angiography and Interventions (SCAI) staging system for CS severity lacks validation in patients with TTS and CS. This study aimed to characterize a patient cohort with TTS using the SCAI staging system and assess its utility in cases of TTS complicated by CS.

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Article Synopsis
  • The study investigates the effects of beta-blocker therapy on long-term outcomes for patients who have recovered from Takotsubo syndrome (TTS), a condition that can be triggered by stress and involves temporary heart dysfunction.
  • Researchers analyzed data from 970 TTS survivors in Spain, assessing whether those treated with beta-blockers had different rates of mortality and TTS recurrence compared to those who were not treated.
  • Results showed no significant differences in survival or recurrence rates between patients on beta-blockers and those not on them, suggesting that beta-blockers may not be beneficial for improving long-term outcomes in TTS patients.
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Introduction: Endothelial dysfunction and platelet activation have been highlighted as possible mediators in Takotsubo syndrome (TTS). Nevertheless, to date, evidence on the usefulness of antiplatelet therapy in TTS remains controversial. The aim of our study is to evaluate long-term prognosis in TTS patients treated with antiplatelet therapy (APT) at hospitalization discharge.

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Objectives: The SYNTAX score and SYNTAX score II have a high predictive capacity for adverse cardiovascular events. We aimed to demonstrate that both scores were good predictors of long-term adverse outcomes in an 'all-comers' population treated with a percutaneous coronary intervention (PCI).

Methods: In the study, we included 785 patients who received an angioplasty at our center between January 2011 and December 2012.

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Background And Objectives: A relationship between neoplasms and Takotsubo syndrome (TS) has been postulated. Our goal was to determine its prevalence in patients with TS, compare the clinical profile of TS with or without cancer and study its long-term evolution.

Materials And Methods: The oncological situation of patients included in the National Registry on TAKOtsubo syndrome (RETAKO), admitted between 2002 and 2019, provided by 38 hospitals throughout the country is analysed.

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Background Takotsubo syndrome (TTS) is an acute reversible heart condition initially believed to represent a benign pathology attributable to its self-limiting clinical course; however, little is known about its prognosis based on different triggers. This study compared short- and long-term outcomes between TTS based on different triggers, focusing on various physical triggering events. Methods and Results We analyzed patients with a definitive TTS diagnosis recruited for the Spanish National Registry on TTS (RETAKO [Registry on Takotsubo Syndrome]).

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Background: Coronary Aneurysms are a focal dilatation of an artery segment >1.5-fold the normal size of adjacent segments. Although some series have suggested a prevalence of 0.

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Article Synopsis
  • - This study aimed to analyze the frequency, causes, and effects of cardiogenic shock (CS) in patients with takotsubo syndrome (TTS), which is linked to serious heart instability.
  • - Out of 711 patients, 11.4% experienced CS, with higher mortality rates and other complications associated with factors like male gender and severe heart function issues at admission.
  • - CS was identified as a major predictor of long-term mortality, emphasizing its seriousness in TTS cases; however, beta-blocker treatment improved survival rates in those with CS at discharge.
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Objective: During cardiology training, the cardiology fellow has to be trained in all things related to the indication, interpretation, and performing of nuclear cardiology studies using single photon emission computed tomography (SPECT). The aim of the present study was to analyse the relationship between the adequacy of indications of myocardial perfusion gated-SPECT and the years of experience since the completion of cardiology training.

Method: A descriptive, retrospective analysis was performed on a single-centre register, in which the indications (adequate or inadequate use) were recorded according to myocardial perfusion gated-SPECT guidelines, prescribed by cardiologists of a university hospital.

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Introduction And Objectives: Rotational coronary angiography (RCA) requires less contrast to be administered and can prevent the onset of contrast-induced nephropathy (CIN) during invasive coronary procedures. The aim of the study is to evaluate the impact of RCA on CIN (increase in serum creatinine ≥0.5mg/dl or ≥25%) after an acute coronary syndrome.

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Unlabelled: Coronary artery aneurysm is defined as a coronary dilation that exceeds the diameter of adjacent segments or the diameter of the patient's largest normal coronary vessel by 1.5×. It is an uncommon disease that has been diagnosed with increasing frequency since the widespread appearance of coronary angiography.

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Background: Takotsubo syndrome (TKS) usually mimics an acute coronary syndrome. However, several clinical forms have been reported. Our aim was to assess if different stressful triggers had prognostic influence on TKS, and to establish a working classification.

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Introduction And Aims: The etiology and epidemiology of tako-tsubo cardiomyopathy remain uncertain. The symptoms of this condition are often similar to those of myocardial infarction and, although it usually has a good prognosis, it is not without complications. Our aim was to characterize this disease in our setting using a dedicated registry (Spanish REgistry for TAKOtsubo cardiomyopathy).

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