Publications by authors named "Alejandro Rubio-Fernandez"

Granulomatous reactions to tattoo ink have been frequently associated with exogenous pigment, although sometimes they are the manifestation of a cutaneous or an underlying systemic sarcoidosis. We report a case of a patient with a granulomatous reaction to a black tattoo pigment treated with 3% topical allopurinol for 3 months. We observed complete resolution without any side-effects.

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Intestinal (tailgut) cysts or retrorectal cystic hamartomas are rare benign lesions that are included in the category of developmental cystic lesions. Their origin is still uncertain, although several hypotheses have been proposed to explain their development. They are located mainly in the presacral (retrorectal) space and predominately affect middle-aged women (40-60 years).

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Article Synopsis
  • Syringocystadenoma papilliferum (SCAP), tubular adenoma (TA), and hydrocystoma (HC) are classified as benign skin tumors that may share a common morphological classification known as Tubulopapillary cystic adenoma with apocrine differentiation (TPCAa).
  • Recent studies have identified mutations in BRAF and K-Ras (KRAS) in SCAP and TA, while such mutations are not found in HC; verrucous epithelial growths have also been noted in TPCAa.
  • The presented case highlights a TPCAa with a specific BRAF mutation (V600E) and demonstrates notable BRAF VE1 immunoh
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  • Hereditary leiomyomatosis (HL) is a rare genetic disorder caused by mutations in the fumarate hydratase (FH) gene, which follows an autosomal dominant inheritance pattern.
  • Patients with HL have a higher likelihood of developing smooth muscle tumors and renal cancer.
  • A case study is presented of a 39-year-old man diagnosed with HLRCC, who showed no family history or notable skin symptoms at the time of his diagnosis.
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Meningiomas have a 5 year recurrence rate of 8%. Histological grade and extent of resection are the two main prognostic factors. Cystic meningiomas represent between 2 and 4% of meningiomas, and the complete resection rate in these cases is 62.

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Renal carcinomas associated with translocation of transcription factors of the MiT/TFE family include, according to the latest World Health Organization classification, carcinomas with Xp11 translocation that involve the TFE3 gene and those with translocation t(6;11)(p21;q12) that affect the TFEB gene. Each one of these sub-types have well-defined clinicopathological and molecular characteristics. Currently, progress in molecular techniques has led to the description of neoplasms with molecular changes in these same genes but with alterations different to translocation.

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The coexistence of two or more tumours in the same patient is unusual, but even rarer is the metastasis of one tumour to another. Most reports are based on evidence from autopsies; very few refer to surgical specimens. The most common primary tumour is pulmonary carcinoma and most frequent metastatic tumour is renal clear cell carcinoma.

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Pseudomyogenic hemangioendothelioma, also called epithelioid sarcoma-like hemangioendothelioma, is a rare, vascular neoplasm usually with indolent behaviour. It was introduced in the latest World Health Organization (WHO) Classification of Tumours of Soft Tissue. We report a case of a 45 year-old patient presenting with a localized, palpable and slightly painful lesion in the left arm.

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