A randomized, double-blind study on the efficacy of oral domperidone versus placebo for reducing SARS-CoV-2 viral load in mild-to-moderate COVID-19 patients in primary health care.

Introduction: The clinical effect of domperidone against COVID-19 has been investigated in a double-blind phase III clinical trial (EudraCT number 2021-001228-17). Domperidone has shown in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and potential immudolatory properties through the stimulation of prolactin secretion.

Patients And Methods: The efficacy of oral domperidone plus standard of care (SOC;  = 87) versus placebo plus SOC ( = 86) was evaluated in a 28-day randomized double-blind multicentre study in primary health care centres.

Prevalence of insulin resistance in a young adult population. Relationship with weight status.

Aim: To estimate the prevalence of insulin resistance using both the Homeostatic Model Assessment (HOMA) index and basal insulinemia, and to analyze its relationship to overweight, as measured by body mass index (BMI) and waist circumference (WC).

Patients And Methods: A series of 118 non-diabetic young adults aged 18 and 19 years attending a primary care health center were studied. They were contacted by telephone, and their BMI, WC, HOMA and basal insulinemia were measured, among other parameters.

[Obesity and cardiovascular risk factors in adolescents. Association with cardiovascular risk factors in first degree relatives].

Background And Objective: Obesity is a major concern in public health. The fact that most teenagers stop contacting the health system during this period of life prevents detection of this problem and its associated morbidity. The aim of this study is to measure the prevalence of obesity at 18.