Monocyte profiles and their association with depression severity and functional disability.

Background: Inflammatory processes have been implicated in the pathophysiology of depression. This study explores the association between the number, proportion and subtypes of monocytes with functional disability and depression severity in a sample of adult patients.

Methods: A cross-sectional study was conducted with 74 participants.

Decoding the inflammatory signature of the major depressive episode: insights from peripheral immunophenotyping in active and remitted condition, a case-control study.

Depression is a prevalent and incapacitating condition with a significant impact on global morbidity and mortality. Although the immune system's role in its pathogenesis is increasingly recognized, there is a lack of comprehensive understanding regarding the involvement of innate and adaptive immune cells. To address this gap, we conducted a multicenter case-control study involving 121 participants matched for sex and age.