Publications by authors named "Alejandro Molina Leyva"
Article Synopsis
- Therapeutic burden (TB) in hidradenitis suppurativa (HS) is a key factor that may predict responses to biologic treatments, highlighting its importance in clinical decision-making.
- A study of 557 HS patients provided insights into the average TB, which was linked to factors such as older age, longer disease duration, and greater disease severity.
- Results indicate that understanding TB can help clinicians better assess when to adjust treatment strategies for HS patients based on their individual severity and treatment history.
Insights into the Window of Opportunity and Outcome Measures in Patients with Moderate to Severe Hidradenitis Suppurativa Treated with Secukinumab: A Real-World Study.
Dermatol Ther (Heidelb)
July 2024
Article Synopsis
- The study investigates the timing of initiating biological therapy (secukinumab) for managing hidradenitis suppurativa (HS) to improve patient outcomes.
- It involves a retrospective analysis of 67 patients who switched to secukinumab after failing previous treatments, with follow-up lasting 24 weeks to evaluate safety and effectiveness.
- Results indicate that 41.79% achieved significant improvement, and a lower therapeutic burden (fewer prior treatments) was linked to better responses, supporting the idea that earlier treatment may be beneficial.
Article Synopsis
- The research evaluates the effectiveness and safety of bimekizumab for treating hidradenitis suppurativa in real-world clinical settings.
- Significant improvements were observed in key activity scores and patient-reported outcomes after 16 weeks, with all results showing a strong statistical significance (p < 0.001).
- Bimekizumab was well-tolerated with no reported discontinuations or new safety issues, reaffirming its favorable safety profile previously seen in phase 3 clinical trials.
Safety and Effectiveness of Percutaneous Ultrasound-Guided Galvanic Current in Tunnels of Patients with Hidradenitis Suppurativa: A Pilot Study.
Dermatol Ther (Heidelb)
May 2024
Article Synopsis
- The study investigates the effectiveness and safety of ultrasound-guided galvanic current (GC) treatment for hidradenitis suppurativa (HS), a chronic skin condition, in patients where traditional treatments may not be sufficient.
- Results showed that 77% of patients experienced a complete response 12 weeks post-treatment, with no serious adverse effects noted.
- Overall, the study concludes that GC is a promising and well-tolerated local treatment option for HS.
Article Synopsis
- Photodynamic therapy (PDT) is a treatment that helps with actinic keratosis (AKs), a skin condition, but we don't know much about how it affects the skin's barrier.
- Researchers studied patients with AKs to see how PDT impacts their skin over time.
- The study found that PDT reduces AKs and changes the skin barrier, leading to some improvements in skin health, especially after a month.
Psoriasis is a chronic inflammatory disease associated with significant impairment in quality of life. Although quality of life in patients with psoriasis has been widely studied, there is little evidence regarding the impact of psoriasis on major life-changing decisions (MLCD). The aims of this study are to describe the impact of psoriasis on MLCD and to explore the potential clinical factors associated with MLCD.
View Article and Find Full Text PDFHidradenitis suppurativa is a chronic inflammatory disorder of the hair follicle with a high level of morbidity. Pilonidal sinus disease is a comorbid disorder and may be the reason for first contact with the healthcare system of patients with hidradenitis suppurativa. The aim of this study was to evaluate the frequency of association of pilonidal sinus disease and hidradenitis suppurativa and to explore whether pilonidal sinus disease defines a different clinical profile for patients with hidradenitis suppurativa.
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- Chronic spontaneous urticaria (CSU) can make people feel sad and have a lower quality of life, especially affecting women more than men.
- A study with 75 patients found that over half of them had sexual dysfunction, which made their condition feel even worse.
- Women with sexual dysfunction and poorly controlled CSU were at a higher risk for anxiety and depression, suggesting that doctors should check for these issues to help patients feel better.
Skin barrier dysfunction plays an important role in atopic dermatitis (AD) aetiopathogenesis. Dupilumab, a drug that inhibits IL-4 and IL-13, is an effective treatment for AD but there is scarce evidence about its impact on epidermal barrier. The objective of this systematic review is to evaluate the influence of dupilumab on skin barrier in patients with AD using non-invasive tools.
View Article and Find Full Text PDFShort-Term Effectiveness, Safety, and Potential Predictors of Response of Secukinumab in Patients with Severe Hidradenitis Suppurativa Refractory to Biologic Therapy: A Multicenter Observational Retrospective Study.
Dermatol Ther (Heidelb)
April 2023
Article Synopsis
- Hidradenitis suppurativa (HS) is a chronic skin condition, and secukinumab, a biologic drug, is being studied for its effectiveness and safety in treating moderate to severe cases over 16 weeks.
- A study involving 47 patients in southern Spain found that nearly 49% achieved significant clinical improvement (HiSCR) after treatment, with only a small percentage experiencing adverse effects.
- Factors such as being female, having a lower body mass index (BMI), and a lower previous treatment burden were linked to a higher likelihood of achieving the desired treatment response.
Sleep Quality as a Predictor of Quality-of-Life and Emotional Status Impairment in Patients with Chronic Spontaneous Urticaria: A Cross-Sectional Study.
Int J Environ Res Public Health
February 2023
Chronic Spontaneous Urticaria (CSU) leads to a decreased quality of life in patients because of pruritus and skin lesions. However, there is still little evidence on the impact that a worse sleep quality could have on the quality of life and emotional disorders in these patients. The aims of the present study are to analyze the potential impact of sleep quality on the quality-of-life and emotional status of patients with CSU.
View Article and Find Full Text PDFPotential Predictors of Cardiovascular Risk Improvement in Patients with Hidradenitis Suppurativa Treated with Adalimumab: A Pivotal Study of Factors Associated with Carotid Intima-Media Thickness Reduction.
Dermatol Ther (Heidelb)
March 2023
Article Synopsis
- Hidradenitis suppurativa (HS) is associated with increased cardiovascular risk (CVR) due to inflammation, and this study investigates how adalimumab treatment affects patients' CVR.
- In a study involving 27 patients with severe HS, while overall carotid intima-media thickness (IMT) showed no significant change after 32 weeks, 40.7% of patients improved their IMT.
- The patients who improved had more classic CVR factors like dyslipidemia and diabetes, suggesting that those with higher atherosclerosis burden and less inflammation might respond better to adalimumab treatment.
Improvement of Sexual Function and Sleep Quality in Patients with Atopic Dermatitis Treated with Dupilumab: A Single-Centre Prospective Observational Study.
Int J Environ Res Public Health
January 2023
Atopic dermatitis (AD) is a chronic inflammatory skin disease presenting as xerosis, eczema and intense pruritus. These symptoms negatively impact patients' quality of life. However, the effect of AD on sexual function and sleep quality and how treatment with dupilumab could modify them have not been explored in depth.
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- A new parameter called IHS4-55, which indicates a 55% reduction in the severity of Hidradenitis Suppurativa (HS), was validated using data from patients treated with adalimumab and placebo.
- The research aimed to externally validate the IHS4-55 in patients treated with antibiotics, assessing its correlation with the reduction of inflammatory lesions and quality of life metrics.
- Results from a study of 283 patients showed that those achieving IHS4-55 experienced significant reductions in inflammatory nodules and had a greater likelihood of improving quality of life scores, supporting its use as a key outcome measure in clinical trials.
Type D Personality as a Marker of Poorer Quality of Life and Mood Status Disturbances in Patients with Skin Diseases: A Systematic Review.
Acta Derm Venereol
January 2023
Type D personality is characterized by social inhibition and negative affectivity. Poorer outcomes and worse quality of life have been linked to type D personality in patients with a variety of non-dermatological diseases. Despite increasing evidence of the importance of type D personality in skin diseases, there are no reviews on this subject.
View Article and Find Full Text PDFArticle Synopsis
- Hidradenitis suppurativa (HS) is a skin disease that affects how people feel and their relationships, not just for the person with the disease but also for their partners.
- The study looked at how HS impacts patients' quality of life (QoL) and the sexual health of both patients and their partners.
- It found that both patients and their partners experience difficulties, especially in sexual function, with various factors like disease severity and body weight affecting their overall quality of life.
Quality of Life and Mood Status Disturbances in Cohabitants of Patients with Alopecia Areata: A Cross-Sectional Study in a Spanish Population.
Int J Environ Res Public Health
December 2022
A poor quality of life has been described in patients suffering from Alopecia Areata (AA). However, there is little evidence on how AA can impact on those living with patients. The aim of this study is to analyze the impact of AA on a cohabitant’s quality-of-life, mood status disturbances and sexual satisfaction.
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