Publications by authors named "Alejandro Lopez-Montes"
Article Synopsis
- Researchers are creating hindbrain organoids from human-induced pluripotent stem cells (iPSCs) to explore how these systems behave in different patients, helping to examine disease progression and treatment responses.
- Using iPSCs derived from healthy individuals and AD patients, they confirmed the presence of serotonergic neurons and found that different organoids showed variable reactions to the antidepressant escitalopram, indicating potential for personalized treatment approaches.
Monte Carlo (MC) simulations are commonly used to model the emission, transmission, and/or detection of radiation in Positron Emission Tomography (PET). In this work, we introduce a new open-source MC software for PET simulation, MCGPU-PET, which has been designed to fully exploit the computing capabilities of modern GPUs to simulate the acquisition of more than 100 million coincidences per second from voxelized sources and material distributions. The new simulator is an extension of the PENELOPE-based MCGPU code previously used in cone-beam CT and mammography applications.
View Article and Find Full Text PDFIn conventional positron emission tomography (PET), only one radiotracer can be imaged at a time, because all PET isotopes produce the same two 511 keV annihilation photons. Here we describe an image reconstruction method for the simultaneous in vivo imaging of two PET tracers and thereby the independent quantification of two molecular signals. This method of multiplexed PET imaging leverages the 350-700 keV range to maximize the capture of 511 keV annihilation photons and prompt γ-ray emission in the same energy window, hence eliminating the need for energy discrimination during reconstruction or for signal separation beforehand.
View Article and Find Full Text PDF'. Dead time correction (DTC) is an important factor in ensuring accurate quantification in PET measurements. This is currently often achieved using a global DTC method, i.
View Article and Find Full Text PDFAim: To evaluate the effect of combining positron range correction (PRC) with point-spread-function (PSF) correction and to compare different methods of implementation into iterative image reconstruction for I-PET imaging.
Materials And Methods: Uniform PR blurring kernels of I were generated using the GATE (GEANT4) framework in various material environments (lung, water, and bone) and matched to a 3D matrix. The kernels size was set to 11 × 11 × 11 based on the maximum PR in water and the voxel size of the PET system.