Publications by authors named "Alejandro Leon Betancourt"
Background And Purpose: Kelchlike protein 11 antibodies (KLHL11-IgGs) were first described in 2019 as a marker of paraneoplastic neurological syndromes (PNSs). They have mostly been associated with testicular germ cell tumors (tGCTs).
Methods: Two patients with KLHL11-IgG encephalitis are reported, and the literature is comprehensively reviewed.
Article Synopsis
- Neuronal autoantibodies, specifically anti-neurochondrin antibodies, play a crucial role in diagnosing primary autoimmune cerebellar ataxia (PACA), a condition that still lacks extensive knowledge and documentation.
- A case study of a 33-year-old man revealed significant symptoms including gait imbalance and cerebellar atrophy over time, leading to a confirmed PACA diagnosis through various tests.
- Early diagnosis and treatment with immunotherapy showed positive outcomes, suggesting that PACA cases associated with anti-neurochondrin antibodies may be underreported, and recognizing them can lead to important therapeutic interventions.
Article Synopsis
- This study looked at the relationship between the absence of a specific MRI sign (susceptibility vessel sign or SVS) and active malignancy in patients with acute ischemic stroke who underwent mechanical thrombectomy.
- The research found that 6.9% of patients had active malignancy, and those without the SVS were significantly more likely to have either active or hidden (occult) malignancy.
- Including SVS status in predictive models improved their performance in identifying malignancy, suggesting it could be a useful marker for detecting related complications in patients with stroke.