Publications by authors named "Alejandro J Alvarellos"
First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus: Latin American Group for the Study of Lupus (GLADEL, )-Pan-American League of Associations of Rheumatology (PANLAR).
Bernardo A Pons-Estel Eloisa Bonfa Enrique R Soriano Mario H Cardiel Ariel Izcovich Alejandro J Alvarellos
Ann Rheum Dis
November 2018
Article Synopsis
- * A study was conducted by rheumatologists and methodologists, leading to the formulation of guidelines addressing common clinical issues faced by SLE patients in the region, based on best available evidence.
- * The guidelines cover nine organ/system sections, focusing on pharmacological treatments, their benefits and risks, and emphasize regional implementation, considering ethnic and socioeconomic factors.
Objective: To identify susceptibility loci for rheumatoid arthritis (RA) in Latin American individuals with admixed European and Amerindian genetic ancestry.
Methods: Genotyping was performed in 1,475 patients with RA and 1,213 control subjects, using a customized BeadArray containing 196,524 markers covering loci previously associated with various autoimmune diseases. Principal components analysis (EigenSoft package) and Structure software were used to identify outliers and define the population substructure.