Publications by authors named "Alejandro Hernandez-Solis"

Article Synopsis
  • Vaccines are crucial for protecting people from infectious diseases and are considered one of humanity's greatest discoveries.
  • The Royal Philanthropic Vaccine Expedition, led by Doctor Francisco Javier de Balmis y Berenguer, plays a significant historical role in vaccine development.
  • In Mexico, the National Vaccination Campaign against COVID-19 started at the Dr. Eduardo Liceaga General Hospital, highlighting the ongoing importance of vaccination efforts.
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Purpose: To describe the clinical features and identify mortality risk factors in descending necrotizing mediastinitis (DNM) complicating deep neck abscesses (DNA) among patients admitted to the ICU.

Methods: A retrospective analysis was conducted on consecutive patients admitted to the ICU of a tertiary care public hospital. Data were collected from July 2017 to July 2024.

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Article Synopsis
  • Allergic bronchopulmonary aspergillosis is a rare immune response to the fungus Aspergillus fumigatus, leading to symptoms like lung inflammation and high eosinophil counts in the blood.
  • A 42-year-old male with diabetes exhibited severe respiratory issues and was found to have high eosinophils and elevated IgE for the fungus; he was treated with oxygen, prednisone, and itraconazole, resulting in improvement.
  • The condition can be deadly, especially in immunocompromised individuals; diabetic patients have a higher prevalence of fungal infections, with nearly 37% potentially affected compared to only 4.7% in non-diabetics.
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Article Synopsis
  • The study aimed to analyze the clinical outcomes, comorbidities, and mortality rates of cancer patients infected with SARS-CoV-2 during the COVID-19 pandemic, along with the health protocols implemented in COVID care centers.!* -
  • Out of 1752 patients in a respiratory care unit, 5% had a prior cancer diagnosis with a distribution of 59.1% having solid tumors and 40.9% hematologic cancers; those with cancer showed lower ICU admission rates (8%) compared to non-cancer patients (17.4%).!* -
  • Despite their cancer status, hospitalized oncology patients with COVID-19 had similar survival rates as non-cancer patients, likely reflecting effective multidisciplinary care strategies
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Surgical resection of the stenotic segment with end-to-end anastomosis is considered the gold standard in postintubation tracheal stenosis. However, outcomes of this concrete aetiology are not well described. With the aim to examine the extent, range and characteristics of the existing evidence, a scoping review was performed.

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Introduction: Patients with respiratory diseases face adverse situations such as symptom management, general condition deterioration, and a hostile perception of the hospital environment, favoring the appearance of anxiety and depression.

Methods: A total of 317 patients hospitalized for a disease of pulmonary origin were analyzed and divided into the following subgroups: infectious, oncological, acute, and chronic diseases. Patients over 18 years of age with preserved cognitive capacity were included in the study.

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Objective: this study evaluated burnout symptoms among physicians and nurses before, during and after COVID-19 care.

Method: a cross-sectional comparative study in the Pulmonary Care unit of a tertiary-level public hospital. The Maslach Burnout Inventory was used.

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is a yeast-like fungus of the Dipodascaceae family, capable of colonizing the skin and the respiratory and gastrointestinal tracts. We present a 56-year-old man with diabetes mellitus who was admitted to the hospital presenting with fever, cough and hemoptysis. The diagnosis of necrotizing pneumonia was made by direct microscopy of the bronchoalveolar lavage fluid showed and was identified by Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight (MALDI-TOF MS®).

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Extrapulmonary tuberculosis is defined as that case of tuberculosis clinically diagnosed and confirmed by bacteriological studies that affects tissues and organs outside the lung parenchyma. Mexico is in third place among Latin American countries in terms of the incidence of pulmonary and extrapulmonary tuberculosis. Culture methods are still the gold standard for the diagnosis of extrapulmonary tuberculosis since they identify the species and susceptibility to drugs.

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The clinical presentation of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranges between mild respiratory symptoms and a severe disease that shares many of the features of sepsis. Sepsis is a deregulated response to infection that causes life-threatening organ failure. During sepsis, the intestinal epithelial cells are affected, causing an increase in intestinal permeability and allowing microbial translocation from the intestine to the circulation, which exacerbates the inflammatory response.

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Most individuals infected with Mycobacterium tuberculosis (Mtb) have latent tuberculosis (TB), which can be diagnosed with tests (such as the QuantiFERON-TB Gold test [QFT]) that detect the production of IFN-γ by memory T cells in response to the Mtb-specific antigens 6 kDa early secretory antigenic target EsxA (Rv3875) (ESAT-6), 10 kDa culture filtrate antigen EsxB (Rv3874) (CFP-10), and Mtb antigen of 7.7 kDa (Rv2654c) (TB7.7).

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Pulmonary histoplasmosis is caused by inhaling . Less than 1% develops the disease. Risk factors in immunocompetent individuals are environmental exposures in endemic areas.

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Introduction: Pulmonary aspergilloma is commonly associated with comorbidities that cause immunodeficiency such as diabetes mellitus, tuberculosis, human immunodeficiency virus/acquired immunodeficiency syndrome and/or a pre-existing parenchymal lung disease such as chronic obstructive pulmonary disease. Predisposing factors can further increase the risk of acquiring this mycosis. Our objective was to determine the frequency, clinical and microbiological characteristics of pulmonary aspergilloma in immunocompromised patients.

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Article Synopsis
  • Sera from patients with active pulmonary tuberculosis (APT) cause significant nuclear changes in normal neutrophils, suggesting that household contacts may have subclinical tuberculosis.
  • * The study found that short contact (30 min) with APT sera enhanced neutrophil phagocytic activity and other immune responses, unlike sera from healthy individuals.
  • * The findings indicate that neutrophils in APT patients may be activated in a way that contributes to disease pathology, preceding potentially harmful nuclear changes.
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Introduction: COVID-19-associated mortality in patients who require mechanical ventilation is unknown in the Mexican population.

Objective: To describe the characteristics of Mexican patients with COVID-19 who required mechanical ventilation.

Methods: Observational cohort study carried out in an intensive care unit from March 25 to July 17, 2020.

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Objective: To describe a Covid-19 outbreak in a gerontological center in Mexico City.

Material And Methods: Cross-sectional study in older adults. The association of risk factors for dying from Covid-19 was analyzed using a multiple logistic regression model.

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It is known that, in ancient Mexico, diseases of the respiratory system were a major cause of death in the population. Severe epidemics in the XVI Century ravaged and killed nine out of ten indigenous persons. Pre-Hispanic physicians served as medical sorcerers and dealt with the physical and spiritual diseases that afflicted the population.

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Background: Diabetes mellitus is a public health problem in Mexico, and the trend of the disease is increasing. From 2000 to 2017, 7.32 million new cases were diagnosed, with pulmonary mycoses being one of the most serious complications.

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Synopsis of recent research by authors named "Alejandro Hernandez-Solis"

  • - Alejandro Hernandez-Solis focuses on respiratory diseases, with a recent systematic review highlighting the surgical treatment of postintubation tracheal stenosis as a crucial area of study, indicating the need for comprehensive assessment of surgical outcomes in this specific context.
  • - His research also addresses the psychological impacts of respiratory diseases, revealing high prevalence rates of depression and anxiety symptoms among hospitalized patients suffering from various pulmonary conditions, emphasizing the importance of mental health interventions in this demographic.
  • - Additionally, Hernandez-Solis investigates the healthcare implications of COVID-19 and its intersection with chronic diseases, particularly diabetes, as well as occupational burnout among healthcare professionals during the pandemic, reflecting a multidisciplinary approach to addressing respiratory health challenges.