Publications by authors named "Alejandro H Armenti"
Article Synopsis
- This study explores the relationship between Trypanosoma cruzi infection and T cell exhaustion, indicating that chronic infection is linked to impaired T cell responses due to the expression of inhibitory receptors like CTLA-4 and LIR-1.
- Researchers found that most IFN-γ-producing CD4(+) T cells in infected patients expressed CTLA-4, particularly in those with severe heart disease, while fewer expressed LIR-1.
- Additionally, CTLA-4 and LIR-1 engagement can diminish IFN-γ production, highlighting how persistent T. cruzi infection may disrupt effective immune responses by increasing these inhibitory receptors.
Introduction And Objectives: The extent to which a patient's socioeconomic conditions determine the persistence or control of chronic Chagas disease has not been previously investigated. The aim of this study was to evaluate the effect of socioeconomic conditions on clinical and serologic measures of disease progression.
Methods: Data on the following socioeconomic variables were obtained by questioning as part of medical history taking at admission: birth in a rural area, time of residence in endemic and urban areas (in years), overcrowding index (i.
Background: Previously, we identified a set of HLA-A020.1-restricted trans-sialidase peptides as targets of CD8+ T cell responses in HLA-A0201+ individuals chronically infected by T. cruzi.
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- The study analyzes how memory CD8(+) T cells mature and migrate in relation to heart disease severity in people with chronic Trypanosoma cruzi infection living outside endemic areas for over 20 years.
- Individuals with mild or no heart issues showed stronger T. cruzi-specific immune responses compared to those with severe cardiac disease, indicating a healthier T cell function.
- As heart disease worsens, there's a shift from early-differentiated CD8(+) T cells to more fully differentiated ones, suggesting that ongoing stimulation by the parasite may lead to T cell exhaustion over time.