Publications by authors named "Alejandro Gonzalez Diaz"

Objective: To assess the diagnostic accuracy of F-Choline PET/CT in the initial staging of high-risk prostate cancer (PC), and to compare it with conventional imaging techniques and to assess the changes in therapeutic attitude derived from its results.

Secondary Objectives: To assess the concordance between F-Choline PET/CT and conventional study and to find related prognostic factors.

Material And Methods: Retrospective observational study of 78 patients with high-risk PC undergoing F-Choline PET/CT after conventional initial staging (CT + BS).

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Introduction: Mitomycin C (MMC) is one of the most frequently utilized intravesical chemotherapy drugs for the management of non-muscle-invasive bladder cancer (NMIBC). Allergic reactions (Type 4 delayed hypersensitivity) are seldomly reported in the literature but not so infrequent in daily practice, its incidence has been increasing with the use of device-assisted hyperthermia. This study aims to identify the incidence, risk factors, and clinical characteristics of patients with allergic reactions to MMC.

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Purpose: The purpose of the study was to compare the outcomes of high-risk non-muscle-invasive bladder cancer (HR-NMIBC) patients treated with BCG vs recirculating hyperthermic intravesical chemotherapy (HIVEC) with mitomycin C (MMC).

Methods: A pilot phase II randomized clinical trial was conducted including HR-NMIBC patients, excluding carcinoma in situ. Patients were randomized 1:1 to receive intravesical BCG for 1 year (once weekly for 6 weeks plus subsequent maintenance) or HIVEC with 40 mg MMC, administered using the Combat BRS system (once weekly instillations were given for 6 weeks, followed by once monthly instillation for 6 months).

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Article Synopsis
  • 1. Background: The study explores the effectiveness of hyperthermic intravesical chemotherapy (HIVEC) using mitomycin-C (MMC) as an alternative treatment for non-muscle invasive bladder cancer (NMIBC), especially during a shortage of BCG therapy.
  • 2. Methods: Researchers conducted an observational trial (HIVEC-E) on NMIBC patients in Spain from 2012 to 2020, evaluating treatment outcomes like recurrence, progression, and overall mortality, while monitoring safety and adverse effects.
  • 3. Results: 502 patients received a median of 8.78 HIVEC MMC treatments over a follow-up of about 24.5 months,
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To analyze, in a urology ward, the prevalence and characteristics of healthcare-associated infections (HAIs) due to multidrug-resistant organisms (MDRO). We carried out an observational study from 2012 to 2019, evaluating MDRO among patients with HAIs, who were hospitalized in the urology ward. MDRO include spp.

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Introduction: Negative ureteroscopy (NURS) is "a ureteroscopy in which no stone is found during the procedure." We aimed to determine the association between the surgical waiting list time (WLT) and the NURS rate.

Methods: We retrospectively analyzed all patients scheduled for ureteroscopy in our center between January 2017 and July 2019.

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Objectives: To propose a clear definition and management pathway of patients with analgesic refractory colic pain (ARCP).

Patients And Methods: Prospective cohort study from February 2018 to February 2019 including patients with ARCP defined as ongoing renal colic pain after one dose of IV NSAID, IV paracetamol, and a parenteral opioid, given sequentially in that order. Patients were observed in-hospital under full parenteral analgesic management for 8-12 h, whenever patients had minimal or absent pain after conservative management (CM) they were discharged, and followed-up with new imaging within four weeks.

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Introduction: Chemohyperthermia (CHT) with mitomycin C (MMC) is together with Bacillus Calmette-Guérin (BCG), and passive MMC, a treatment option for patients with non muscle-invasive bladder cancer. There are no data published about the impact of CHT in quality of life (QoL). We evaluated QoL and adverse events (AE) in this 3-arm observational study.

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Objectives: Urological patients usually come up with risk factors for developing infections. Some of these are caused by multidrug-resistant microorganisms like Pseudomonas aeruginosa, whose notable resistance rates to antibiotics and aggressiveness make its treatment a challenge in clinical practice. Our objective was to analyze Pseudomonas aeruginosa infections incidence, risk factors and features in patients admitted to a Urology Ward in a tertiary care university hospital in Spain.

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Objectives: To determine if self-visualization of ambulatory cystoscopy provides a decrease in pain perception in male and female patients.

Methods: A quasi-randomized controlled trial involving patients scheduled for ambulatory cystoscopy from August to November 2017. The indications were: hematuria, bladder cancer surveillance, lower urinary tract symptoms, and incontinence.

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Purpose: Our purpose is to present the results of our working group, with a view to reduce the incidence and improve the management of healthcare-associated infections (HAIs) in a urology ward.

Methods: The study consists on an observational database designed with the view to analyse the incidence and characteristics of HAIs in Urology. Based on the results obtained, a critical evaluation was carried out and specific measures put in place to reduce HAIs.

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Atrial aneurysms are rare entities that can be congenital or acquired. Those involving the free wall or atrial appendage are even rarer. There are only 49 cases reported in the literature involving the left atrium and 8 in the right atrium until 2002.

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