A new opportunity for N-acetylcysteine. An outline of its classic antioxidant effects and its pharmacological potential as an epigenetic modulator in liver diseases treatment.

Liver diseases represent a worldwide health problem accountable for two million deaths per year. Oxidative stress is critical for the development of these diseases. N-acetyl cysteine (NAC) is effective in preventing liver damage, both in experimental and clinical studies, and evidence has shown that the pharmacodynamic mechanisms of NAC are related to its antioxidant nature and ability to modulate key signaling pathways.

In vitro analysis of postbiotic antimicrobial activity against Candida Species in a minimal synthetic model simulating the gut mycobiota in obesity.

Gut fungal imbalances, particularly increased Candida spp., are linked to obesity. This study explored the potential of Lactiplantibacillus plantarum cell-free extracts (postbiotics) to modulate the growth of Candida albicans and Candida kefyr, key members of the gut mycobiota.

Associations between bacterial and fungal communities in the human gut microbiota and their implications for nutritional status and body weight.

This study examined the interplay between bacterial and fungal communities in the human gut microbiota, impacting on nutritional status and body weight. Cohorts of 10 participants of healthy weight, 10 overweight, and 10 obese individuals, underwent comprehensive analysis, including dietary, anthropometric, and biochemical evaluations. Microbial composition was studied via gene sequencing of 16S and ITS rDNA regions, revealing bacterial (bacteriota) and fungal (mycobiota) profiles.

State identification for a class of uncertain switched systems by differential neural networks.

This paper presents a non-parametric identification scheme for a class of uncertain switched nonlinear systems based on continuous-time neural networks. This scheme is based on a continuous neural network identifier. This adaptive identifier guaranteed the convergence of the identification errors to a small vicinity of the origin.

Design and Analysis of a Rotational Mixer to produce 3D Bioprinting Gyroid-Helical-Patterned Scaffolds for Tissue Engineering Applications.

Tissue engineering scaffolds require complex networks for nutrient diffusion and cell attachment. They must have specific surface area and curvature, and often need a multimaterial composition, demanding advanced micro-fabrication methods. 3D extrusion bioprinting offers versatility to manufacture different scaffold, and strategies for multimaterial printing have been introduced.

Electromyographic signals analysis to assess the response of a proprioceptive neuromuscular facilitation pattern execution.

Proprioceptive Neuromuscular Facilitation is a rehabilitation technique that consists of the stimulation of a healthy muscle in one extremity of the body to produce an activation effect of a damaged muscle in another extremity, laterally or contralaterally. The use of the analysis of the electromyographic response during the process allows us to describe and evaluate if the damaged muscle produces an activation. This paper presents the progress of the results of a clinical protocol where PNF is explored in healthy subjects, manipulating the upper limb, and recording the electromyographic response of the lower limbs in three different muscles in both inferior limbs.

Modeling bacteria pairwise interactions in human microbiota by Sparse Identification of Nonlinear Dynamics (SINDy).

The gut microbiota is a community of high complexity; its composition changes due to ecological interactions, these are studied to understand the relationship with the human health. External stimuli like the administration of probiotics, prebiotics, or drugs are known to modify these interactions. The high complexity of microbiota composition can be studied by considering pairwise interactions.

Review on Porous Scaffolds Generation Process: A Tissue Engineering Approach.

Porous scaffolds have been widely explored for tissue regeneration and engineering three-dimensional models. In this review, a comprehensive literature analysis is conducted to identify the steps involved in their generation. The advantages and disadvantages of the available techniques are discussed, highlighting the importance of considering pore geometrical parameters such as curvature and size, and summarizing the requirements to generate the porous scaffold according to the desired application.

Choroidal Thickness Is a Biomarker Associated With Response to Treatment in Ankylosing Spondylitis.

Objective: Choroidal thickness (CT) has been evaluated as a marker of systemic inflammation in ankylosing spondylitis (AS). This study evaluates the CT of AS patients before and after 6 months of biological treatment.

Methods: This longitudinal multicenter study evaluated CT in 44 AS patients.

Assessment of the water quality of a subtropical lake using the NSF-WQI and a newly proposed ecosystem specific water quality index.

A Water Quality Index (WQI) is a formulation that enables the estimation of the overall quality of a water body based on significant parameters. One example of this is the well-known and widely accepted NSF-WQI, which is frequently used to assess chemical, physical, and microbiologic features of waterbodies in temperate latitudes. In this work, a well-structured method, completely based on multivariate statistical methods and historical data distributions, was used to develop an ecosystem specific water quality index (ES-WQI).

Measuring Choroid Thickness as a Marker of Systemic Inflammation in Patients With Ankylosing Spondylitis.

Background And Objective: Ankylosing spondylitis (AS) is an inflammatory disease, and choroidal thickness (CT) has been proposed and evaluated as a potential marker of systemic inflammation associated with AS and other inflammatory diseases. This study compared CT measurements taken from patients with severe AS disease activity without eye inflammation with those taken from healthy subjects.

Methods: This cross-sectional, multicenter study compared CT in 44 patients with high AS disease activity, and no history of eye inflammation with CT in 44 matched healthy subjects aged between 18 and 65 years.

Multivariate water quality analysis of Lake Cajititlán, Mexico.

Lake Cajititlán is a shallow body of water located in an endorheic basin in western Mexico. This lake receives excess fertilizer runoff from agriculture and approximately 2.3 Hm per year of poorly treated wastewater from three municipal treatment plants.

Hemodynamic Pattern Recognition During Deception Process Using Functional Near-infrared Spectroscopy.

Deception is considered a psychological process by which one individual deliberately attempts to convince another person to accept as true what the liar knows to be false. This paper presents the use of functional near-infrared spectroscopy for deception detection. This technique measures hemodynamic variations in the cortical regions induced by neural activations.

Platform for the study of virtual task-oriented motion and its evaluation by EEG and EMG biopotentials.

This paper presents a platform to study the relationship between upper limb kinematic and biopotential measurements. The platform comprises of a haptic joystick, biopotential acquisition systems and 3D rendered virtual tasks that require user interaction. The haptic joystick, named TeeR, reproduces the pronation-supination and flexion-extension movements of the human arm, which are directly mapped to a 2D graphic display.