Publications by authors named "Alejandro Casas Herrera"

Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with loss of lung function, poor quality of life, loss of exercise capacity, risk of serious cardiovascular events, hospitalization, and death. However, patients underreport exacerbations, and evidence suggests that unreported exacerbations have similar negative health implications for patients as those that are reported. Whilst there is guidance for physicians to identify patients who are at risk of exacerbations, they do not help patients recognise and report them.

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Article Synopsis
  • Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder linked to lung diseases like COPD, and its prevalence in Colombia is unclear despite recommendations for testing all COPD patients.
  • A study was conducted with 1,107 adult COPD patients across seven care centers in Colombia to assess AATD-related mutations using samples from the oral mucosa.
  • Results revealed that 13.01% of patients had genetic mutations, with only 2.07% having AATD-related mutations, highlighting the need for better diagnosis and awareness of this condition.
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Background: Acknowledgement of COPD underdiagnosis and misdiagnosis in primary care can contribute to improved disease diagnosis. PUMA is an international primary care study in Argentina, Colombia, Venezuela and Uruguay.

Objectives: To assess COPD underdiagnosis and misdiagnosis in primary care and identify factors associated with COPD underdiagnosis in this setting.

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Streptococcus pneumoniae is responsible for several clinical syndromes, such as community-acquired pneumonia, sinusitis, otitis media, and others. The most severe clinical entity caused by this bacteria is undoubtedly invasive pneumococcal disease. Certain factors are known to increase the risk of presenting invasive pneumococcal disease, the most important being smoking habit and underlying concomitant diseases.

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