Publications by authors named "Alejandro Burlon"
Article Synopsis
- - The study aimed to assess how melanoma cells (B16-F0) respond to DNA double strand breaks (DSBs) after being exposed to various types of radiation, specifically focusing on the impact of low and high linear energy transfer (LET) radiation.
- - Researchers measured cell survival and DSBs through clonogenic assays and the detection of gammaH2AX foci at different time points after exposure, revealing that higher LET radiation led to a greater effectiveness in inducing DSBs.
- - The findings indicated that the size of gammaH2AX foci could be used as a reliable measure to understand how effectively DSBs are repaired and how sensitive the cells are to the different types of radiation, with larger foci
The effects of copper and cadmium on metabolism through the pentose phosphate pathway were evaluated in Bufo arenarum toad ovary. The effects of the two metals on dehydrogenases from this pathway were evaluated by three experiments: (1) in samples obtained from control females with addition of the metals to the reaction mixture (in vitro), (2) in samples obtained from control females and after long-term exposure of females to 4 and 100 microg/L of Cu or Cd in the incubation media (in vitro after exposure to the metals in vivo), and (3) 14CO2 production through the pentose phosphate pathway was evaluated after [U-14C]glucose microinjection on ovulated oocytes (in vivo after microinjection of the metals). Results from (1) evidenced inhibition of both enzyme activities but only above 1.
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