Publications by authors named "Alejandro Brigante"
Objectives: The need for glucocorticoid-sparing drugs (GCSD) remains an important issue and is an unmet need in the treatment of polymyalgia rheumatica (PMR). We therefore aimed to assess the effectiveness and safety of methotrexate (MTX) and of leflunomide (LEF) in daily clinical practice in PMR patients from Argentina.
Methods: A multicentre and observational study (medical records review) of PMR patients seen between 2007 and 2023, who had at least three months of follow-up after starting a GCSD, either MTX or LEF, was performed.
Objectives: To evaluate the trajectory of students enrolled in the specialty training in rheumatology.
Methods: Retrospective analysis (2009-2016). Promotion, repetition, and dropout rates were determined.
Objective: To assess the time from completion to publication of randomized controlled trials (RCTs) on connective tissue diseases (CTDs), investigate the factors associated with, and explore the influence of significance of study results on time to publication (time-lag publication bias).
Methods: We included interventional, phase 2/3, 3, or 4 RCTs on CTDs registered in Clinicaltrials.gov from 2000 to 2016, whose results had been published in a peer-review journal less than 5 years after their completion.
Background: In polymyalgia rheumatica (PMR) relapses and long-term GC dependency are common. We assessed risk factors for higher relapse rate and/or prolonged glucocorticoid therapy in PMR patients.
Methods: A multicenter and observational study (chart review) of PMR patients seen between 2006 and 2021 who had at least a 3-month follow-up period after starting GCs was performed.
Article Synopsis
- The study assessed the rate and reasons for discontinuation and nonpublication of randomized controlled trials (RCTs) related to connective tissue diseases (CTDs), finding that about 33% were discontinued mainly due to insufficient patient recruitment.
- Out of 130 studies that started, 35% remained unpublished, highlighting a significant discrepancy in publication rates between completed (81%) and discontinued studies (22%).
- The research concluded that the high noncompletion and nonpublication rates indicate a waste of resources and pose ethical concerns about undisclosed clinical data and the involvement of patients in these trials.
Background: The analysis of the main features of randomized controlled trials (RCTs) on ANCA-associated vasculitis (AAV) can inform future study design.
Methods: We searched within the International Clinical Trials Registry Platform all registered RCTs on AAV from October 2008 to December 2018. Two reviewers selected studies according to pre-specified eligibility criteria.
Changing rate of serious infections in biologic-exposed rheumatoid arthritis patients. Data from South American registries BIOBADABRASIL and BIOBADASAR.
Clin Rheumatol
August 2019
Objective: Most reports on serious infections (SI) in rheumatoid arthritis (RA) patients treated with biological disease-modifying antirheumatic drugs (bDMARDs) are from the USA and Western Europe. Data from other regions are largely missing. We report data from South American countries with different backgrounds and health-care systems but similar registries.
View Article and Find Full Text PDFBackground: Diffuse alveolar haemorrhage (DAH) is a manifestation of several immune and nonimmune diseases.
Objective: The objective of this study was to characterize the clinical characteristics and short-term outcomes of patients with immune-mediated DAH requiring hospital admission.
Methods: A retrospective study from December 2010 to December 2015, was conducted by analyzing the clinical records of 39 patients with DAH with a proven immunological origin.