Publications by authors named "Alejandro Bottale"
Introduction: Steam sterilization has been used for decades to effectively kill microbial contaminants in a variety of medical and commercial settings. One of the most critical aspects of safe operations in biosafety level 3 biocontainment laboratories (BSL-3) is the effective inactivation of biological select agents in the waste generated in these environments. The Instituto Nacional de Enfermedades Virales Humanas "Dr.
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- - Candid#1 is the first live attenuated vaccine developed in Argentina since 2003 to prevent Argentine hemorrhagic fever, produced by using an attenuated strain of the Junin virus.
- - The study assessed the stability of Candid#1 under various conditions: the reconstituted vaccine remained stable for 8 days at 2 °C to 8 °C, while the lyophilized version was stable for 30 days at the same temperature and 9 years at -18 °C to -20 °C.
- - As a result of the findings, changes were made to storage and transport protocols, leading to the installation of domestic freezers at key locations to maintain vaccine quality for distribution.