Publications by authors named "Alejandro Andrade"
Health systems have committed their path to universal health coverage using health planning to accomplish their goals of efficiency, equity and sustainability. Chile, a high-income country with a public-private mix health system, has made significant progress through several successive health policies implemented in the last 20 years which have been consistent with this approach. However, in the last 5 years, the national congress has produced several disease-specific laws, which have been mainly promoted by the civil society.
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- Before tyrosine kinase inhibitors (TKIs) were introduced, patients with Philadelphia-positive Acute Lymphoblastic Leukemia (Ph+ALL) had poor outcomes; the combination of TKIs with intense chemotherapy has significantly improved these results.
- A study conducted on 35 patients at a public hospital in Santiago, Chile, between 2010 and 2019 showed a 97% complete response rate, and 61% had no measurable residual disease (MRD) during follow-up.
- While the overall survival and event-free survival rates at three years were 52% and 34% respectively, achieving MRD negativity before three months did not significantly improve these outcomes, suggesting the combined treatment is an effective option for Ph+
Technological advancement provides an unprecedented amount of high-frequency data of human dynamic processes. In this paper, we introduce an approach for characterizing qualitative between and within-subject variability from quantitative changes in the multi-subject time-series data. We present the statistical model and examine the strengths and limitations of the approach in potential applications using Monte Carlo simulations.
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- - Bisphenol A (BPA) is a common endocrine-disrupting chemical found in over 92% of humans, known to affect fetal brain development by altering gene expression in key brain regions.
- - This study focused on the impact of BPA exposure during pregnancy on gene expression in specific brain areas of mice, discovering 259 differentially expressed genes (DEGs) linked to various neurodevelopmental and behavioral processes.
- - Notably, some of these DEGs are associated with autism spectrum disorders, and key regulators were identified, including huntingtin and estrogen receptors, suggesting significant implications for understanding BPA's effects on brain function.
Ascaris lumbricoides infection affects approximately 1.5 billion people globally. Children with environmental and socio-economic risk factors are more susceptible to infestation, with serious complications such as intestinal obstruction (IO), volvulus, intussusception, and intestinal necrosis.
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- Hematopoietic stem cell transplantation (HSCT) is an effective treatment for blood-related diseases like lymphoma and multiple myeloma, and was integrated into Chile's National Cancer Program in 2004, transitioning from private to public services by 2008.* -
- The study reports on the first ten HSCT procedures performed at the new national center, which adhered to evidence-based protocols and received approval from a national commission.* -
- Among the ten patients treated, a majority experienced mild side effects but showed positive outcomes, with successful neutrophil and platelet recovery by days 10 and 11, respectively, leading to a conclusion that the center can serve as a model for public care, education, and research
The Racial Microaggressions Scale (RMAS): a new scale to measure experiences of racial microaggressions in people of color.
Cultur Divers Ethnic Minor Psychol
April 2012
Racial microaggressions refer to the racial indignities, slights, mistreatment, or offenses that people of color may face on a recurrent or consistent basis. Racial microaggressions may represent a significant source of stress endured by people of color. The purpose of this study was to develop a scale to measure racial microaggressions.
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- - In 2009, the World Health Organization declared the novel H1N1 influenza A virus a pandemic, leading to numerous cases and deaths globally, particularly impacting South American countries like Chile during their winter season.
- - A specific case is reported involving a liver transplant patient in Chile who experienced severe complications from H1N1 shortly after surgery, resulting in the need for extended mechanical ventilation.
- - The case emphasizes the importance of early detection and treatment of H1N1 in vulnerable patients and aims to educate healthcare providers on prevention, diagnosis, and management strategies amidst the ongoing pandemic.