Publications by authors named "Alejandro Alarcon-Del-Carmen"
Article Synopsis
- - The circadian clock system regulates various bodily functions in a 24-hour cycle and disruptions can lead to conditions like obesity and Type 2 diabetes.
- - This study investigates how the spatial arrangement of the genome changes in response to diet, particularly how it affects circadian transcription in liver cells of lean and obese mice.
- - Findings reveal daily changes in chromatin interactions linked to metabolic genes, showing that high-fat diets modify gene expression through specific regulatory mechanisms that help the body adapt its metabolism to dietary changes.
Adipocytes are the main cell type in adipose tissue, which is a critical regulator of metabolism, highly specialized in storing energy as fat. Adipocytes differentiate from multipotent mesenchymal stromal cells (hMSCs) through adipogenesis, a tightly controlled differentiation process involving close interplay between metabolic transitions and sequential programs of gene expression. However, the specific gears driving this interplay remain largely obscure.
View Article and Find Full Text PDFBackground: Gastric cancer is a heterogeneous disease associated to deregulated gastric epithelia tight junction barrier function and di novo expression of claudin-6; these changes are associated with epithelial-mesenchymal transition, enhanced invasiveness, metastatic progression, resistance to chemotherapy, and poor prognosis. Gastric cancer stem cells represent a rare population of cells within the tumor implicated in tumor growth and higher tumorigenic capacity. The possible relation between claudin-6 expression and the expression of some markers associated to epithelial mesenchymal transition and cancer stem cells in gastric cancer cells have never been explored.
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