Prospective randomized clinical trial: single and weekly viscosupplementation.

Objective: To compare two different dosages of an intermediate molecular weight sodium hyaluronate (HA) (Osteonil(®)-TRB Pharma) assessing whether a single 6 ml application of this HA has the same effectiveness as the classical three-weekly 2 ml dose.

Methods: 108 patients with knee osteoarthritis were randomized into two groups of 54 patients each. The groups were designated "single" (S) and "weekly" (W).