Publications by authors named "Alejandro A Zagal-Salinas"
Article Synopsis
- Food-grade titanium dioxide (E171) has been linked to potential health risks, but its specific toxic effects on cells have not been fully explored.
- The study investigated how E171 affected endoplasmic reticulum (ER) function in normal, carcinoma, and adenocarcinoma colon cells by exposing these cells to various concentrations for up to 72 hours.
- Results showed that E171 caused ER stress and altered key cellular responses, with adenocarcinoma cells absorbing more titanium, but similar ER-related effects were observed across all cell types at different exposure levels.
Food grade titanium dioxide E171 has been used in products such as confectionery, doughs and flours to enhance organoleptic properties. The European Union has warned about adverse effects on humans due to oral consumption. After oral exposure, E171 reaches the bloodstream which raises the concern about effects on blood cells such as monocytes.
View Article and Find Full Text PDFBackground: Food-grade titanium dioxide (E171), a white colourant widely used in ultra-processed food products, has been banned in the European Union. However, its usage is still permitted in medicines, and in several other countries. The estimated intake of E171 in children is higher than in adults, which led us to hypothesise that E171 induces differential effects depending on age, with adult mice being the most susceptible due to age, despite the lower dose.
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