Background: The use of propofol is controversial in patients with a history of acute pancreatitis or those taking drugs, including certain chemotherapeutic drugs, that are associated with pancreatitis.
Methods: To investigate this issue, we reviewed the medical records of all children who were diagnosed with pancreatitis while receiving chemotherapy for acute leukemia during a 5-year period.
Results: A temporal relationship between propofol use and development of acute pancreatitis could not be established.
Background: The combination of propofol and remifentanil may be particularly suitable for short-duration procedures such as lumbar puncture. The authors undertook a two-part study to evaluate coadministration of propofol and remifentanil as an anesthetic technique for lumbar puncture in children.
Methods: The first part was a sequential allocation dose-finding study to determine the minimum effective dose of remifentanil when coadministered with 2.