Publications by authors named "Alejandra Silvia Scazziota"
Article Synopsis
- Neurohormonal systems activate early in acute coronary syndromes to help maintain blood circulation, but long-term activation of these stress hormones can be harmful.
- Cortisol levels peak at 8 hours after symptoms start, with consistently high levels linked to poorer outcomes, while catecholamines surge significantly within 30 minutes of ischemia, worsening heart damage.
- Stress-related high blood sugar leads to inflammation, vascular issues, and increased risk of blood clots, and notably, hyperglycemia in non-diabetic patients is associated with higher in-hospital and 12-month mortality rates.
Background: Platelet activation is crucial in normal hemostasis. Using a clotting system free of external tissue factor, we investigated whether activated Factor VII in combination with platelet agonists increased thrombin generation (TG) in vitro.
Methods And Results: TG was quantified by time parameters: lag time (LT) and time to peak (TTP), and by amount of TG: peak of TG (PTG) and area under thrombin formation curve after 35 minutes (AUC-->35min) in plasma from 29 healthy volunteers using the calibrated automated thrombography (CAT) technique.