Publications by authors named "Alejandra S H Cottliar"
Article Synopsis
- Mantle cell lymphoma (MCL) is a specific type of cancer linked to a genetic abnormality involving the chromosomes, and this study focused on how telomere length (TL) could be related to its characteristics.
- The research involved analyzing DNA from 20 MCL patients, finding that their mean telomere length was significantly shorter than that of healthy controls, indicating possible implications for cancer development.
- Despite variations in age, sex, and clinical stages, the study concluded that telomere length reduction in MCL patients did not correlate with these factors or with different cellular features, suggesting a fundamental link in MCL regardless of clinical details.
Telomeres are essential for maintaining chromosomal integrity and stability. We studied here telomere length (TL) in bone marrow and/or lymph node from 36 patients: 29 with follicular lymphoma (FL) at diagnosis and 7 with diffuse large B cell lymphoma secondary to FL (S-DLBCL). TL was evaluated using terminal restriction fragments (TRF) assay.
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