Publications by authors named "Alejandra Mendez-Serrano"
Increased micronucleus frequencies in reticulocytes of children exposed to industrial pollution: oxidative stress and the OGG1 S326C polymorphism.
Regina D Montero-Montoya Rocío López-Vargas Alejandra Méndez-Serrano Isaías Galicia-Alonso Guadalupe García-Vargas
Mutat Res Genet Toxicol Environ Mutagen
May 2020
We examined possible early-effect biomarkers and polymorphisms of susceptibility in primary school children living near the Atoyac River in central México, which receives waste from multiple industries. We observed a significant increase in micronucleated reticulocytes associated with the oxidative stress index (OSI) and the OGG1 GG (S326C) genotype, and a significant decrease of reticulocytes carrying the transferrin receptor, inversely correlated with OSI.
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- The Atoyac River is highly polluted, impacting about 1.5 million people and local farmland, prompting a study on health effects in nearby communities.
- A comparison of schoolchildren from polluted areas versus a cleaner town revealed significantly higher oxidative stress in those living by the river.
- Findings suggest early biological effects on health in polluted environments, underscoring the need for better environmental protections and monitoring.