Publications by authors named "Alejandra Garcia Garcia"

In this work, we employed a novel microwave-assisted synthesis method to produce nitrogen and boron co-doped carbon dots (B-N co-doped CDs). To achieve optimal synthesis, we conducted a comprehensive parameter modulation approach, combining various synthesis temperatures, times, and precursor concentrations, while keeping the power constant at 150 W and pH 5. Using maximum fluorescence emission as our response variable, the best conditions were identified as 120 °C, 3 min, and a precursor concentration of 1 mg/mL.

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  • Enzyme-based biosensors, particularly those using laccase enzymes, offer a promising alternative for detecting contaminants like over-the-counter medications, despite challenges in real-world applications.
  • The study develops bioelectrodes using laccase isoforms from a native Mexican fungus, comparing their efficacy with a commercial enzyme for detecting acetaminophen in environmental samples.
  • Results show that the best-performing laccase (LacII) achieved a low limit of detection (LOD) of 0.2 µM in a buffer and 0.5 µM in groundwater, indicating high sensitivity and efficacy compared to existing biosensor technologies.
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Groundwater is one of the primary sources of water for both drinking and industrial use in northeastern Mexican territory, around 46% of the total, due to the lack of precipitation during the year and solar radiation index. The presence of arsenic in brackish soil and groundwater is a severe health issue, specifically in semi-arid and arid regions in the north of Mexico. Additionally, it represents the only source of drinking water in communities far from big cities, mainly due to the absence of hydric infrastructure.

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The surface modification of materials obtained from natural polymers, such as silk fibroin with metal nanoparticles that exhibit intrinsic electrical characteristics, allows the obtaining of biocomposite materials capable of favoring the propagation and conduction of electrical impulses, acting as communicating structures in electrically isolated areas. On that basis, this investigation determined the electrochemical and electroconductive behavior through electrochemical impedance spectroscopy of a silk fibroin electrospun membrane from silk fibrous waste functionalized with gold or silver nanoparticles synthetized by green chemical reduction methodologies. Based on the results obtained, we found that silk fibroin from silk fibrous waste (SF) favored the formation of gold (AuNPs-SF) and silver (AgNPs-SF) nanoparticles, acting as a reducing agent and surfactant, forming a micellar structure around the individual nanoparticle.

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  • Heart failure is a common issue among the elderly, often leading to symptoms related to fluid congestion, which can be evaluated using clinical signs, imaging tests, and increasingly, ultrasound methods.
  • This study examines how effective lung ultrasound and inferior vena cava (IVC) measurements can be in predicting mortality risk in elderly heart failure patients who are admitted to the hospital.
  • Findings from the study involving 482 patients indicated that those with more than 6 B-lines on lung ultrasound and IVC collapsibility of less than 50% had significantly higher mortality rates within 30 days, highlighting the utility of these ultrasound techniques in assessing patient prognosis.
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Objective: The role of hypertension in COVID-19 has not been clearly elucidated yet. The aim of this study was to evaluate the incidence and severity of COVID-19 in a hypertensive population and assess whether there is a link between blood pressure control and SARS-CoV-2 infection outcomes.

Methods: This was a single-center retrospective observational study that evaluated the incidence and severity of COVID-19 in a chronic hypertensive population (n=1,637) from a specialized consultation of Hypertension and Cardiovascular Risk of Internal Medicine in a tertiary hospital in Madrid (Spain).

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Tissue engineering has focused on the development of biomaterials that emulate the native extracellular matrix. Therefore, the purpose of this research was oriented to the development of nanofibrillar bilayer membranes composed of polycaprolactone with low and medium molecular weight chitosan, evaluating their physicochemical and biological properties. Two-bilayer membranes were developed by an electrospinning technique considering the effect of chitosan molecular weight and parameter changes in the technique.

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The prevalence and incidence of heart failure (HF) have been increasing in recent years as the population ages. These patients show a distinct profile of comorbidity, which makes their care more complex. In recent years, the PROFUND index, a specific tool for estimating the mortality rate at one year in pluripathology patients, has been developed.

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The incidence and prevalence of heart failure (HF) is increasing worldwide, leading to high morbidity and mortality. The global management of HF involves lifestyle changes in addition to pharmacological treatments. Changes include exercise and dietary recommendations, mainly salt and fluid restriction, but without any clear evidence.

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Background: Whether immunosuppressed (IS) patients have a worse prognosis of COVID-19 compared to non-IS patients is not known. The aim of this study was to evaluate the clinical characteristics and outcome of IS patients hospitalized with COVID-19 compared to non-IS patients.

Methods: We designed a retrospective cohort study.

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Objectives: To analyze the prevalence of May-Thurner syndrome (MTS) among patients with deep vein thrombosis (DVT) of left lower limb (LLL), and outcomes after long-term follow-up.

Method: Retrospective observational study that included patients older than 18 diagnosed with acute DVT and MTS.

Results: Among 760 patients diagnosed with DVT in the LLL, 8 patients were diagnosed with MTS (1.

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The influence of the lateral size and the content of graphene oxide (GO) flakes in specific oxygenate functional groups on the anti-biofouling properties and performance of thin-film composite membrane (TFC) was studied. Three different multidimensional GO samples were prepared with small (500-1200 nm), medium (1200-2300 nm), and large (2300-3600 nm) size distribution, and with different degrees of oxidation (GO3 > GO2 > GO1), varying the concentration of the hydrogen peroxide amount during GO synthesis. GO1 sheets' length have a heterogeneous size distribution containing all size groups, whilst GO2 is contained in a medium-size group, and GO3 is totally contained within a small-size group.

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Introduction: Inferior vena cava agenesis (IVCA) is a rare and underdiagnosed congenital anomaly that predisposes to deep vein thrombosis (DVT). Optimal duration of anticoagulant treatment in these patients is not well established.

Method: Observational retrospective study that included all consecutive patients older than 18 diagnosed with IVCA and DVT.

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In this work, copper selenide (CuSe umangite phase) was synthesized by two routes, using a chemical reaction and the hydrothermal method to obtain CuSe-A and CuSe-H, respectively. The synthesis of CuSe consisted of a three-step process: in the first step, copper(I) oxide hexapods (CuO) were obtained as the copper reservoir; in the second step, selenium ions were obtained from the reduction of selenium powder; and in the third step involves mixing two precursors following the two synthesis routes mentioned before. Analysis of X-ray diffraction and X-ray photoelectron spectroscopy showed the formation of the CuSe phase by both synthesis routes.

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Intrinsic radiosensitivity is a biological parameter known to influence the response to radiation therapy in cancer treatment. In this study, Raman spectroscopy and surface enhanced Raman spectroscopy (SERS) were successfully used in conjunction with principal component analysis (PCA) to discriminate between radioresistant (LY-R) and radiosensitive (LY-S) murine lymphoma sublines (L5178Y). PCA results for normal Raman analysis showed a differentiation between the radioresistant and radiosensitive cell lines based on their specific spectral fingerprint.

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Background: There is limited evidence on the etiology and outcomes of renal infarction. A provoking factor is identified only in one- to two-thirds of patients.

Methods: This is a retrospective observational study.

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Behçet's Disease (BD) is a rare, chronic and recurrent inflammatory multisystemic condition of unknown origin that can affect any tissue. The vascular system is involved in 5-40% of cases of BD, including venous and arterial beds and it has a relapsing course. Budd-Chiari syndrome (BCS) is a rare complication of BD with a frequency of < 5% among patients with vascular involvement and is more frequent in men (89.

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Spruce wood (picea abis) has been widely used as structural element, from buildings to musical instruments, due to its outstanding mechanical performances. The main stem transverse section exhibits growth rings formed by periodic fringes patterns, which are constituted by lamellae-tracheid arrangements. In order to improve the understanding of each wood microstructure role, the morphology and crystallinity of earlywood and latewood fibers were examined mainly using scanning electron microscopy, atomic force microscopy, and X-ray difracction.

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In this study, bimetallic nanoparticles (BMNPs) with different mass ratios of Cu and Fe were evaluated. The influence of the morphology on the removal of pollutants was explored through theoretical and experimental studies, which revealed the best structure for removing arsenate (As(V)) in aqueous systems. To evidence the surface characteristics and differences among BMNPs with different mass proportions of Fe and Cu, several characterization techniques were used.

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Leptomeningeal involvement of CLL is usually underdiagnosed as neurological symptoms are unspecific. It is important to carefully evaluate neurological status in these patients and consider this entity between the differential diagnosis of a neurological deterioration as adequate treatment improves the prognosis. Imaging techniques, analyses of cerebrospinal fluid, and brain biopsy are useful to establish a definitive diagnosis.

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Introduction: Actinomycosis is a chronic bacterial infection caused by , Gram-positive anaerobic bacteria. Its symptomatology imitates some malignant pelvic tumours, tuberculosis, or nocardiosis, causing abscesses and fistulas. Actinomycoses are opportunistic infections and require normal mucous barriers to be altered.

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Surface modification in nanostructured mesoporous silica particles (MSNs) can significantly increase the uptake in myocardial cells. Herein, MSNs particles were synthesized and chemically functionalized to further assess their biocompatibility in rat myocardial cell line H9c2. The surface modification resulted in particles with an enhanced cellular internallization (3-fold increase) with respect to pristine particles.

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