Perinatal Cytomegalovirus Infection.

Purpose Of Review: There have been recent advances in the field of congenital CMV infection (cCMV) related to antiviral treatment of pregnant women and infants, the implementation of newborn CMV screening programs, and the frequency and diagnosis of complications among infected children. In addition, postnatal CMV infection (pCMV) is increasingly recognized as a potential cause of long-term sequelae in addition to acute complications among preterm infants, raising important questions related to treatment, and prevention.

Recent Findings: High-dose valacyclovir appears to be safe and effective for the prevention of cCMV among women with first-trimester primary CMV infection.

Uncertainty of runoff sensitivity to climate change in the Amazon River basin.

We employ the approach of Roderick and Farquhar (2011) to assess the sensitivity of runoff (R) given changes in precipitation (P), potential evapotranspiration (E ), and other properties that change the partitioning of P (n) by estimating coefficients that predict the weight of each variable in the relative change of R. We use this framework using different data sources and products for P, actual evapotranspiration (E), and E within the Amazon River basin to quantify the uncertainty of the hydrologic response at the subcatchment scale. We show that when estimating results from the different combinations of datasets for the entire river basin (at Óbidos), a 10% increase in P would increase R on average 16%, while a 10% increase in E would decrease R about 6%.

[Osteoporosis-pseudoglioma Syndrome: a pediatric case of primary osteoporosis].

Osteoporosis should be considered in children with severe chronic diseases or in association with some genetic diseases that bear an increased risk of bone fragility. Primary osteoporosis is an entity in which emerging aetiologies are being recognized. Its association with congenital retinal folds should guide the diagnosis to the Osteoporosis-Pseudoglioma syndrome (OMIM 259770), a rare disease (prevalence of 1/2 000 000), caused by the loss of function of the protein LRP5 (low-density lipoprotein receptor-related protein 5) resulting in the alteration of the Wnt/β-catenin signalling pathway.

Focusing Conservation Efforts on Ecosystem Service Supply May Increase Vulnerability of Socio-Ecological Systems.

Growing concern about the loss of ecosystem services (ES) promotes their spatial representation as a key tool for the internalization of the ES framework into land use policies. Paradoxically, mapping approaches meant to inform policy decisions focus on the magnitude and spatial distribution of the biophysical supply of ES, largely ignoring the social mechanisms by which these services influence human wellbeing. If social mechanisms affecting ES demand, enhancing it or reducing it, are taken more into account, then policies are more effective.

Spanish adaptation of the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R).

ALSFRS-R is a tool designed to measure disease progress in ALS patients. It consists of 12 items grouped into four functions designed to assess disabilities according to the Activities of daily living (ADL). Our objective was to validate the Spanish version of ALSFRS-R based on the original version.