Publications by authors named "Alejandra Bermudez-Garcia"
Objective: To describe the inflammatory profile of asymptomatic hyperuricemia (AH) with ultrasound evidence of monosodium urate (MSU) crystals (AH-MSUpos), vs AH without deposits (AH-MSUneg), intercritical gout, and normouricemia.
Methods: Based on serum urate levels, musculoskeletal ultrasound, and history of flares, we divided 122 participants into four groups: normouricemia, AH-MSUneg, AH-MSUpos, and intercritical gout. We tested four ultrasound definitions for MSU deposition in AH: grade 2-3 (G2-3) double contour and/or tophi, G1-3 double contour and/or tophi, G1-3 Stewart scheme (double contour sign in knee cartilage and/or first metatarsophalangeal joint and/or tophi in first metatarsophalangeal joint), and G2-3 Stewart scheme.
Article Synopsis
- The study aimed to identify a sonographic protocol for assessing urate crystal deposits in patients with asymptomatic hyperuricemia (AH) and determine how different definitions affect deposition rates and related features.
- A total of 77 participants were evaluated using ultrasound across 10 locations to identify different types of urate deposits and their associated inflammation and erosions.
- Results showed a wide range in deposition rates depending on the protocols used, emphasizing the need for a standardized definition to better understand and manage AH.