Cell Mol Life Sci
May 2022
Background: Mood disorders have been associated with risk of clinical relapses in multiple sclerosis (MS), a demyelinating disease mediated by myelin-specific T cells.
Objectives: We aimed to investigate the impact of major depressive disorder (MDD) and cytokine profile of T-cells in relapsing remitting MS patients.
Methods: For our study, plasma and PBMC were obtained from 60 MS patients (30 with lifetime MDD) in remission phase.