Publications by authors named "Aleida S Dias"
Article Synopsis
- Chronic hepatitis C (CHC) is linked to liver damage due to the immune response to HCV antigens, with high levels of IL-1β, IL-6, and IL-17 found in patients.
- A notable increase in core-specific IL-6 and IL-17 T cells occurs in patients with more severe liver lesions, as shown by the Metavir scale.
- CHC patients have an elevated percentage of Treg cells, particularly those with advanced fibrosis, but a low proportion of CD39 Treg subsets, indicating an imbalance in T cell populations associated with liver fibrosis severity.
Studies have suggested the pivotal role of T helper type 1 (Th1) -related cytokines on the outcome of hepatitis C virus (HCV) infection. Nevertheless, the role of different interleukin-17 (IL-17) -secreting T cells on chronic hepatitis C (CHC) is less clear. Here, the in vivo IL-1β, IL-6, and IL-17 levels were positively correlated with both alanine transaminase (ALT) levels and hepatic lesions.
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