Publications by authors named "Alei Xu"
Article Synopsis
- The study evaluates how F-FDG-PET/CT imaging combined with clinicopathological factors can help differentiate between primary lung cancer (PLC) and breast cancer metastasis (BCM) in patients with solitary pulmonary nodules (SPNs) following breast cancer treatment.* -
- It involved 120 breast cancer patients, comparing clinicopathological characteristics and imaging features to identify significant differences, particularly in tumor markers and metabolic activities related to SPNs.* -
- Key findings suggest that certain imaging features and serum markers, like SUV and specific signs on CT scans, are predictive factors that can aid in accurately diagnosing SPNs in this patient population.*
Objective: Radioresistance of tumor cells is a major factor associated with failure of radiotherapy (RT). This study aimed to investigate the effect of BRCA1 knockdown on MDA-MB231 breast cancer cell radiosensitivity.
Materials And Methods: Short hairpin RNA (shRNA) was used to knockdown BRCA1 gene in MDA-MB231 cells.
The heterogeneity of triple negative breast cancer (TNBC) results in the worst prognosis among breast cancer types, making its treatment strategy very challenging. A recent study showed that oleanolic acid (OA) has a radiosensitizing effect on tumor cells, but it does not show a good clinical effect when used alone in radiotherapy. The cytotoxicity of radiotherapy can be enhanced by modulating DNA repair, so new treatment options are being investigated to inhibit DNA repair pathways and sensitize tumors to radiation.
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