Publications by authors named "Alec Z Sandroni"
Objectives: The early molecular events after intervertebral disc injury remain unclear. In this study, we aimed to compare inflammatory markers from 1 day to 4 wks after injury to have a comprehensive understanding of the intervertebral disc response to injury.
Design: Mouse tail intervertebral disc injury was induced by a needle puncture.
Objective: To examine the effects of human interleukin (IL) 8 expression on mouse behavior.
Methods: A mouse line expressing human IL8 in the intervertebral discs (IVD) and cartilaginous tissues ( ) was generated. Mouse spontaneous behaviors, including locomotion, climbing, rearing, grooming, eating, drinking, and immobility were recorded with a fully automatic, non-invasive platform.