Publications by authors named "Alec Thomas Salminen"
Article Synopsis
- Drug-induced liver injury in children (cDILI) is rare, making up about 1% of all adverse drug reactions and a significant portion of acute liver failure cases in kids, but studies show that their susceptibility might be more drug-specific than previously assumed.
- Certain drugs, such as valproic acid and dactinomycin, are more likely to cause cDILI, while others, like deferasirox and isoniazid, are associated with liver injury in adults (aDILI) instead.
- There is a critical knowledge gap in understanding the differences in how children and adults react to liver injuries caused by medication, as current animal models and diagnostic tools are lacking.
