Publications by authors named "Alec Koss"
Article Synopsis
- RA T cells in patients with rheumatoid arthritis may have altered metabolism, which can worsen autoimmune symptoms.
- A pilot study on 12 sedentary RA participants showed that a 10-week high-intensity interval training program improved cardiorespiratory fitness and influenced T cell and muscle oxidative metabolism.
- The improvements in fitness were linked to better T cell respiration and changes in muscle metabolism, suggesting that exercise could help manage immune and muscle dysfunction in RA patients.
Background: Exercise training, including high-intensity interval training (HIIT), improves rheumatoid arthritis (RA) inflammatory disease activity via unclear mechanisms. Because exercise requires skeletal muscle, skeletal muscle molecular pathways may contribute. The purpose of this study was to identify connections between skeletal muscle molecular pathways, RA disease activity, and RA disease activity improvements following HIIT.
View Article and Find Full Text PDFObjective: To evaluate how frequently surfactant is used off-label in preterm infants.
Study Design: We conducted a retrospective cohort analysis of prospectively collected administrative data for 2005-2015 from 348 neonatal intensive care units in the US. We quantified off-label administration of poractant alfa, calfactant, or beractant in inborn infants born at <37 weeks of gestational age (GA).